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[Non-steroidal anti-inflammatory agents. XXII. Chiral aryl-hydroxy-fluorenylpropionic acids]
S Burnelli1, L Varoli, A Guarnieri
1Dipartimento di Scienze Farmaceutiche, Università degli Studi di Bologna.
Bollettino Chimico Farmaceutico
|April 1, 1991
Abstract:
As fluorenyl rigid analogues of previous biphenylyl alcanoic acids with very interesting antiinflammatory activity, the 3-(m-tolyl and m-anisyl)-3-hydroxy-3-(2-fluorenyl)-propionic acids have been prepared by means of the Reformatsky reaction and following hydrolysis of the obtained ethyl esters. The preliminary antiinflammatory assay showed that the structural modification inactivates the compounds.