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Updated: Jul 13, 2026

Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis
Published on: August 29, 2025
Carbohydrate metabolism changes in cystic fibrosis
Angela Domínguez-García1, Sofía Quinteíro-González, Luis Peña-Quintana
1Paediatric Endocrinology Unit, Paediatrics Service, Hospital Universitario Materno Infantil de Canarias, Las Palmas, Spain. argdom@wanadoo.es
Aims:
To assess the prevalence of impaired glucose tolerance (ITG) and diabetes mellitus (DMRCF) in a group of patients with cystic fibrosis (CF). To study clinical status-related variables and to compare age with the evolution of their carbohydrate metabolism (CHM).
Patients And Methods:
Thirty patients with CF (1.5-26 years). Oral glucose tolerance test (OGTT) in 28 patients.
Results:
Three patients (10%) showed ITG and four DMRCF (13.3%). CF patients with impaired CHM (ICHM) were older (p = 0.006), and had longer times since diagnosis and first sputum colonization (p = 0.001, p < 0.001). Homozygous deltaF508 mutation was significant (p = 0.001). Insulin peak, area under the curve for insulin, insulin resistance, insulin sensitivity, and pancreatic beta-cell function were all significant.
Conclusions:
ICHM was present in 23.3%. Age, time since diagnosis of CF, first sputum colonization and homozygous deltaF508 mutation were significantly associated. CHM in patients with CF is similar to that in the population without CF in the early years.
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