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Related Experiment Videos

Amulet string contact leukoderma and its differentiation from vitiligo.

Kalyan Banerjee1, Raghubir Banerjee, Biswajit Mandal

  • 1Dept. of Dermatology, University College of Medicine, Goenka Hospital, Kolkata, India. drkalyanbanerjee@yahoo.com

Indian Journal of Dermatology, Venereology and Leprology
|July 24, 2007
PubMed
Summary
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Contact leukoderma, a form of vitiligo, was caused by a nylon thread in a silver amulet. Patch testing confirmed the thread, not the silver, as the cause of the skin depigmentation.

Area of Science:

  • Dermatology
  • Occupational Health
  • Toxicology

Background:

  • Contact leukoderma is a depigmentation of the skin resulting from external contact with certain chemicals.
  • Occupational exposure to various substances can lead to skin conditions, including vitiligo-like presentations.
  • Identifying the causative agent is crucial for diagnosis and management of contact leukoderma.

Purpose of the Study:

  • To investigate the cause of a linear depigmented patch on a factory worker's arm.
  • To determine if the depigmentation was occupationally induced and linked to a silver amulet.
  • To confirm the specific component responsible for the contact leukoderma.

Main Methods:

  • Clinical examination of the depigmented skin patch.
  • Patch testing with the nylon thread of the amulet.

Related Experiment Videos

  • Patch testing with dyes extracted from the amulet.

    • Main Results:

    • A linear depigmented patch consistent with vitiligo was observed on the patient's right arm.
    • Patch testing revealed that the nylon thread of the amulet was the causative agent.
    • Extracted dyes from the amulet did not induce a reaction, ruling them out as the cause.

    Conclusions:

    • The patient's contact leukoderma was definitively caused by the nylon thread used to affix the silver amulet.
    • This case highlights the importance of thorough patch testing to identify occupational contact leukoderma triggers.
    • Nylon threads should be considered as potential allergens in cases of suspected contact leukoderma.