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Skin changes in internal malignancy.

Ravi Rajagopal1, P N Arora, C V Ramasastry

  • 1Dept of Dermatology, 5 Air Force Hospital, C/o 99 APO, India. ravi_rajagopal@rediffmail.com

Indian Journal of Dermatology, Venereology and Leprology
|July 24, 2007
PubMed
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Skin changes are common in internal malignancy patients, with 27.3% showing alterations. Cutaneous metastases and non-specific lesions like acquired ichthyosis were significant findings in this Indian study.

Area of Science:

  • Oncology
  • Dermatology
  • Internal Medicine

Background:

  • Skin changes are frequently observed in patients with internal malignancies.
  • These changes can manifest as specific infiltrates or non-specific alterations.
  • Understanding the frequency of these skin manifestations is crucial for early detection and management.

Purpose of the Study:

  • To determine the frequency of skin changes in patients attending a malignant disease treatment center in India.
  • To differentiate between specific infiltrates (metastases) and non-specific skin lesions.
  • To identify statistically significant non-specific skin changes associated with internal malignancies.

Main Methods:

  • A cohort of 300 patients with confirmed internal malignancy was studied.

Related Experiment Videos

  • Histopathology was used to confirm specific infiltrates (cutaneous metastases).
  • Statistical analysis compared non-specific lesions in patients versus 300 controls without malignancy.

    • Main Results:

    • Skin changes were observed in 82 (27.3%) of the patients.
    • Cutaneous metastases occurred in 19 (6.3%) patients.
    • Statistically significant non-specific skin changes included acquired ichthyosis, herpes zoster, and generalized pruritus.

    Conclusions:

    • Cutaneous metastases typically appear late in the course of internal malignancy.
    • In rare cases, such as histiocytic lymphoma and non-Hodgkin's lymphoma, skin lesions can precede the diagnosis.
    • Contiguous nodules may indicate relapse after surgery for internal malignancy.