Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Candidiasis01:20

Candidiasis

Candidiasis is a fungal infection caused by opportunistic species of Candida. It can affect various anatomical sites, including the skin, oral cavity, nails, and genitourinary tract. Among its forms, vaginal candidiasis is the most common type of mucosal infection. It typically results from the overgrowth of Candida albicans in the vaginal mucosa. Under normal conditions, C. albicans exists as a commensal organism within the vaginal microbiota, regulated by the dominance of lactobacilli, which...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Antifungal Agents01:15

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...
Necrosis01:16

Necrosis

Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become anucleated and die, but their...
Leishmaniasis01:30

Leishmaniasis

Leishmaniasis is a protozoal disease caused by species of the genus Leishmania and transmitted through the bite of infected female sandflies. The parasite exists in two principal morphological forms during its life cycle. A sandfly acquires intracellular amastigotes from an infected reservoir host, such as a dog. Within the sandfly, these forms differentiate into motile, flagellated promastigotes. During a subsequent blood meal, promastigotes are injected into the human host, where they...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The importance of HPV testing in oropharyngeal cancer in two US populations.

Neoplasia (New York, N.Y.)·2026
Same author

Threshold cost of delivering preventive treatment for household contacts of people with multidrug-resistant TB.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2026
Same author

Covid-19 and Its Arthritic Footprint: Clinical, Laboratory and Imaging Insights from a Cross Sectional Study in a Tertiary Center in Telangana.

Mymensingh medical journal : MMJ·2026
Same author

Total neoadjuvant therapy in early-onset versus average-onset locally advanced rectal cancer: patient characteristics and tolerance of therapy.

ESMO gastrointestinal oncology·2026
Same author

Temporal control of decidual inflammation by HOXA10 is essential for implantation and its dysregulation is associated with early pregnancy loss.

Life sciences·2025
Same author

First photographic records of aberrant white feathers in the threatened Lear's macaw Anodorhynchus leari, with further notes on its breeding behavior.

Brazilian journal of biology = Revista brasleira de biologia·2025

Related Experiment Video

Updated: Jul 13, 2026

Examination of Oral Candida Infection in Primary Sjögren's Syndrome Patients
05:26

Examination of Oral Candida Infection in Primary Sjögren's Syndrome Patients

Published on: March 1, 2024

Onycholysis caused by Candida krusei.

S D Rao1, S Wavare, S Patil

  • 1Department of Microbiology, BLDEA's Shri BM Patil Medical College, Bijapur - 586 103, Karnataka, India.

Indian Journal of Medical Microbiology
|July 24, 2007
PubMed
Summary

Candida krusei rarely causes onycholysis, leading to nail changes. This case highlights resistance to fluconazole and amphotericin-B, with successful treatment using clotrimazole and terbinafine.

Area of Science:

  • Medical Mycology
  • Dermatology
  • Clinical Case Study

Background:

  • Onycholysis, or nail plate separation from the bed, is infrequently associated with fungal infections.
  • Candida krusei is an opportunistic yeast with emerging antifungal resistance, rarely implicated in onycholysis.

Purpose of the Study:

  • To report a rare case of onycholysis caused by Candida krusei in a young adult male.
  • To document the diagnostic process and treatment outcomes for this unusual fungal nail infection.

Main Methods:

  • Clinical presentation of grayish nail discoloration and elevation.
  • Potassium hydroxide (KOH) preparation of subungual debris to identify fungal elements.
  • Culture on Sabouraud dextrose agar and identification of Candida krusei via morphological and biochemical testing.

More Related Videos

Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis
08:48

Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis

Published on: March 19, 2019

Related Experiment Videos

Last Updated: Jul 13, 2026

Examination of Oral Candida Infection in Primary Sjögren's Syndrome Patients
05:26

Examination of Oral Candida Infection in Primary Sjögren's Syndrome Patients

Published on: March 1, 2024

Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis
08:48

Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis

Published on: March 19, 2019

  • Antifungal susceptibility testing to guide treatment.

    • Main Results:

    • The patient presented with refractory onycholysis unresponsive to fluconazole.
    • Identification confirmed Candida krusei, exhibiting resistance to fluconazole and amphotericin-B.
    • The isolate was susceptible to nystatin and clotrimazole.

    Conclusions:

    • Candida krusei can cause onycholysis, even in immunocompetent individuals.
    • Antifungal resistance patterns in Candida krusei necessitate susceptibility testing for effective treatment.
    • Combination therapy with clotrimazole and terbinafine proved effective in this challenging case.