Related Experiment Video
Updated: Jul 13, 2026
08:23
Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
Published on: November 5, 2019
Sickle cell disease and the kidney.
Abdou Niang1, Boucar Diouf, Fatou S Ndiaye Sene
1Clinique Médicale 1, Centre hospitalier Universitaire A. Le Dantec, Dakar, Senegal.
Summary
Sickle cell disease (SCD) in West Africa presents diverse renal changes, including chronic glomerulonephritis and renal failure. Early diagnosis and multidisciplinary care are crucial for managing these kidney complications.
Area of Science:
- Nephrology
- Hematology
- Public Health
Background:
- Sickle cell disease (SCD) is prevalent in West Africa, yet its renal manifestations and outcomes remain under-characterized.
- Understanding the spectrum of kidney disease in SCD patients is vital for improving patient management.
Purpose of the Study:
- To retrospectively investigate the types and prevalence of renal abnormalities in West African patients with sickle cell trait (AS) and sickle cell disease (SS).
- To characterize the renal outcomes and histopathological findings in this population.
Main Methods:
- Retrospective analysis of 22 renal patients with sickle cell hemoglobin (19 AS, 3 SS) between 1996 and 2002.
- Review of clinical data, diagnoses of nephropathies, and renal biopsy findings in a subset of patients.
Main Results:
- Common nephropathies included chronic glomerulonephritis (36.3%), advanced chronic renal failure (31.8%), and chronic tubulointerstitial nephropathy (18.1%).
- Renal biopsies revealed conditions such as membranoproliferative glomerulonephritis, focal and segmental glomerulosclerosis, and membranous glomerulonephritis.
Conclusions:
- Sickle cell disease is associated with a variety of renal abnormalities in the West African population.
- Optimal management necessitates early diagnosis and a multidisciplinary approach for effective follow-up and treatment.
Related Concept Videos
01:24Chronic Kidney Disease II: Clinical Manifestations
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
01:25Chronic Kidney Disease I: Introduction
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
01:28Kidney Transplant I: Introduction
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
01:10Nephrons
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma happens...
01:28Chronic Kidney Disease III: Interprofessional Care
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
01:45Kidney Structure
The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.