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Updated: Jul 13, 2026

An Immature Murine Model of Reversible Unilateral Ureteral Obstruction

An Immature Murine Model of Reversible Unilateral Ureteral Obstruction

Published on: April 4, 2025

Pediatric obstructive uropathy: clinical trials.

James Cm Chan¹, Jonathan I Scheinman, Karl S Roth

¹Professor of Pediatrics, University of Vermont and Director of Research, The Barbara Bush Children's Hospital, Maine Medical Center, Portland, Maine, USA.

Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia

|July 24, 2007

Summary

New molecular therapies require trained researchers for clinical trials. Developing molecular markers is crucial for studying pediatric kidney disease progression and treatment effectiveness.

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Last Updated: Jul 13, 2026

An Immature Murine Model of Reversible Unilateral Ureteral Obstruction

An Immature Murine Model of Reversible Unilateral Ureteral Obstruction

Published on: April 4, 2025

Area of Science:

Molecular biology and disease pathogenesis
Pediatric nephrology and clinical research

Background:

Advancements in molecular biology are leading to novel therapeutic approaches.
Evaluating these new treatments necessitates robust clinical trial designs and experienced investigators.
Chronic pediatric kidney disease presents challenges in clinical trials due to slow progression and delayed diagnosis.

Purpose of the Study:

To highlight the need for trained clinical research investigators.
To emphasize the critical role of molecular markers in pediatric kidney disease research.
To review clinical trial principles using examples in pediatric obstructive uropathy-associated kidney disease.

Main Methods:

Review of general clinical trial design principles.
Illustrative examples from current and past studies.
Focus on applications within pediatric chronic kidney disease, specifically related to obstructive uropathy.

Main Results:

Identification of the need for specialized training in clinical research.
Emphasis on the importance of molecular markers for diagnosis and monitoring disease progression.
Demonstration of how clinical trials can be adapted for slowly progressing pediatric conditions.

Conclusions:

The emergence of molecular therapies necessitates a skilled clinical research workforce.
Molecular markers are essential for advancing therapeutic studies in pediatric kidney diseases.
Effective clinical trial design is key to evaluating new treatments for chronic pediatric kidney conditions.