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Related Concept Videos

Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
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Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...

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Related Experiment Video

Updated: Jul 13, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

Hereditary punctate palmoplantar keratoderma--a clinical study.

R R Mittal1, A Jha

  • 1Dept. of Dermatovenereology, Govt. Medical College & Rajinder Hospital, Patiala-147 001, Punjab.

Indian Journal of Dermatology, Venereology and Leprology
|July 24, 2007
PubMed
Summary

Hereditary punctate palmoplantar keratoderma (HPPK) presents diverse clinical patterns. This study classified 28 HPPK patients into major (Group A) and minor (Group B) categories based on palmoplantar keratoderma severity.

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Last Updated: Jul 13, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

Area of Science:

  • Dermatology
  • Genetics
  • Medical Research

Background:

  • Hereditary punctate palmoplantar keratoderma (HPPK) is a rare genetic skin disorder.
  • Characterized by distinct palmoplantar keratoderma (PPK) patterns, HPPK requires detailed classification for understanding its clinical spectrum.

Purpose of the Study:

  • To classify and analyze the clinical presentation of hereditary punctate palmoplantar keratoderma (HPPK) in a cohort of patients.
  • To differentiate between HPPK cases where palmoplantar keratoderma is a major versus a minor feature.

Main Methods:

  • Retrospective analysis of 28 patients diagnosed with hereditary punctate palmoplantar keratoderma (HPPK).
  • Patients were categorized into Group A (PPK as major feature) and Group B (PPK as minor feature).
  • Detailed examination of palmoplantar keratoderma patterns within each group.

Main Results:

  • Out of 28 HPPK patients, 11 were classified into Group A and 17 into Group B.
  • Group A showed scattered punctate PPK (6 patients) or scattered punctate plus focal plaques (5 patients).
  • Group B exhibited various patterns including KPPC (6), KPPC with focal (6), focal plus scattered punctate (3), and diffuse with superimposed KPPC (2).

Conclusions:

  • Hereditary punctate palmoplantar keratoderma (HPPK) exhibits significant clinical heterogeneity.
  • Classification into major and minor PPK features aids in describing the diverse dermatological manifestations of HPPK.