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Updated: Jul 13, 2026

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity

Published on: September 16, 2011

Drugs causing fixed drug eruptions: confirmed by provocation tests.

¹Dept. of Dermatology, Vidya Sagar Institute of Mental and Neuro-sciences, Nehru Nagar, New Delhi.

Indian Journal of Dermatology, Venereology and Leprology

|July 24, 2007

Summary

Fixed drug eruptions, often caused by Co-trimoxazole, can lead to cosmetic issues. Oral provocation tests are crucial for accurately identifying the specific drug responsible for these recurrent skin reactions.

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Last Updated: Jul 13, 2026

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity

Published on: September 16, 2011

Basophil Activation Test for Allergy Diagnosis

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

Area of Science:

Dermatology
Pharmacology
Clinical Medicine

Background:

Drug reactions are common in dermatological practice.
Fixed drug eruption (FDE) can cause significant cosmetic concerns due to recurrence and hyperpigmentation.
Identifying the causative agent is essential for patient management.

Purpose of the Study:

To identify the specific causative drugs in patients with fixed drug eruption.
To evaluate the efficacy of oral provocation testing in diagnosing FDE.

Main Methods:

Forty patients diagnosed with fixed drug eruption were included in the study.
Oral provocation tests were performed using all suspected drugs.
Clinical presentation and affected sites were documented.

Main Results:

Co-trimoxazole was identified as the most frequent cause of FDE (21 patients).
Other identified causative drugs included oxyphenbutazone (9), metamizole (3), tetracycline hydrochloride (3), and piroxicam (1).
The lips were the most commonly affected site (14 patients), followed by genitals, arms, face, and legs.

Conclusions:

Oral provocation testing is the most reliable method for confirming the causative drug in fixed drug eruption.
Accurate diagnosis through provocation testing helps avoid false incrimination of medications.
Understanding common FDE triggers like Co-trimoxazole aids in clinical management.