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Gastritis II: Pathophysiology

Gastritis II: Pathophysiology

The pathophysiology of gastritis begins with the colonization of the stomach lining by Helicobacter pylori (H. pylori). This bacterium spreads mainly via the oral-oral route through saliva or shared utensils, and can also be transmitted in overcrowded or unhygienic environments through contaminated water, despite its brief survival outside the body.ColonizationOnce ingested, H. pylori enters the stomach and begins colonization by navigating through the mucus layer lining the stomach wall. It...

Peptic Ulcer Disease II: Pathophysiology

Peptic Ulcer Disease II: Pathophysiology

Peptic ulcer disease develops when protective mechanisms of the gastrointestinal mucosa are overwhelmed by harmful factors, leading to localized erosions in the stomach or proximal duodenum. The main causes are Helicobacter pylori infection and chronic use of nonsteroidal anti-inflammatory drugs (NSAIDs).Helicobacter pylori–Induced InjuryBacterial Adaptation and Colonization:H. pylori is a spiral, Gram-negative bacterium adapted to the acidic stomach. and transmitted through oral-oral or...

Peptic Ulcer Disease II: Pathophysiology

Peptic Ulcer Disease II: Pathophysiology

Peptic Ulcer Disease (PUD) is characterized by the development of ulcers in the stomach or duodenal mucosa. Its pathophysiology is complex, involving a balance between damaging and protective elements.
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.

Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy

Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy

Helicobacter pylori, a resilient gram-negative bacterium, can thrive in the stomach's harsh, acidic environment. Infection with H. pylori leads to a cascade of events within the stomach lining. One of the critical disruptions caused by this bacterium is the interference with somatostatin production, a hormone responsible for regulating acid secretion. This interference tips the balance, escalating acid secretion and diminishing bicarbonate levels. This imbalance compromises the defensive...

Peptic Ulcer Disease I: Introduction

Peptic Ulcer Disease I: Introduction

Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...

Peptic Ulcer Disease I: Introduction

Peptic Ulcer Disease I: Introduction

Peptic ulcer disease (PUD) involves breaks in the gastrointestinal tract's mucosal lining, primarily in the stomach and duodenum, with less frequent occurrences in the lower esophagus or near the pylorus.Ulcers can be acute or chronic. Acute ulcers are short-lived with minimal inflammation and heal quickly after the irritant is removed. Chronic ulcers persist, may recur, and often cause scarring due to ongoing tissue damage. Superficial erosions affect only the mucosal layer and are called...

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Updated: Jul 13, 2026

Profiling Luminal pH in Three-Dimensional Gastrointestinal Organoids Using Microelectrodes

Profiling Luminal pH in Three-Dimensional Gastrointestinal Organoids Using Microelectrodes

Published on: July 5, 2024

Psoriasis and Helicobacter pylori.

S Qayoom¹, Q M Ahmad

¹Dept. of Dermatology, STD and Leprosy, Govt. Medical College and Associated SMHS Hospitals, Srinagar, Kashmir (J&K).

Indian Journal of Dermatology, Venereology and Leprology

|July 24, 2007

Summary

Helicobacter pylori infection may be linked to psoriasis. This study found higher rates of H. pylori antibodies in psoriasis patients compared to healthy individuals, suggesting a potential connection.

Area of Science:

Dermatology
Gastroenterology
Microbiology

Background:

Emerging evidence suggests a link between Helicobacter pylori (H. pylori) infection and various dermatological conditions.
H. pylori, a bacterium infecting gastric mucosa, has been implicated in conditions like urticaria, rosacea, Sjogren's syndrome, and Henoch-Schonlein purpura.
Its potential role in triggering psoriasis is under investigation.

Purpose of the Study:

To investigate the seroprevalence of Helicobacter pylori in patients with clinically diagnosed psoriasis.
To determine if H. pylori infection is more common in psoriasis patients than in a healthy control group.

Main Methods:

Conducted Helicobacter pylori serology tests on 50 patients with typical psoriasis.
Recruited an equal number of healthy individuals as a control group.

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Profiling Luminal pH in Three-Dimensional Gastrointestinal Organoids Using Microelectrodes

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Published on: July 5, 2024

Quantitative Polymerase Chain Reaction (qPCR)-Based Rapid Diagnosis of Helicobacter pylori Infection and Antibiotic Resistance

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Excluded psoriatic patients with known gastrointestinal complaints.

Main Results:

Significantly higher prevalence of Helicobacter pylori sero-positivity was observed in psoriatic patients compared to the control group (P < 0.05).
Antibodies to H. pylori were detected more frequently in individuals with psoriasis.

Conclusions:

The findings suggest a significant association between Helicobacter pylori infection and psoriasis.
H. pylori may be a contributing factor or trigger for psoriasis development.
Further research is warranted to elucidate the pathogenic mechanisms linking H. pylori and psoriasis.