Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Drug Toxicity: Allergic Reactions

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...

Local Anesthetics: Adverse Effects

Local Anesthetics: Adverse Effects

While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...

Allergic Reactions: Anaphylaxis

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...

Allergic Drug Reactions

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...

Toxic Reactions: Overview

Toxic Reactions: Overview

When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...

Drug Toxicity: Overview

Drug Toxicity: Overview

Drug toxicity quantifies the harm a compound causes to an organism, varying by dose and potentially impacting whole systems or specific organs like the liver. Toxic reactions may arise from venomous insect or spider bites, with effects ranging from mild symptoms to severe outcomes such as brain damage or death. Common forms of acute poisoning include ethanol intoxication and overdose of pain or fever medications, with substances like GHB and heroin being particularly lethal at doses close to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Competition between electron pairing and phase coherence in superconducting interfaces.

Nature communications·2018

Same author

Seroprevalence of coinfections among blood donors in tertiary health care centre of Jammu region.

Indian journal of medical microbiology·2015

Same author

Evaluation of H2 receptor antagonists in chronic idiopathic urticaria.

Indian journal of dermatology, venereology and leprology·2010

Same author

Congenital syphilis - stigmata.

Indian journal of dermatology, venereology and leprology·2010

Same author

Aids patient presenting with common skin diseases.

Indian journal of dermatology, venereology and leprology·2010

Same author

Chrysotherapy in psoriasis.

Indian journal of dermatology, venereology and leprology·2010

Search research articles

Related Experiment Video

Updated: Jul 13, 2026

Eye Irritation Test (EIT) for Hazard Identification of Eye Irritating Chemicals using Reconstructed Human Cornea-like Epithelial (RhCE) Tissue Model

Eye Irritation Test (EIT) for Hazard Identification of Eye Irritating Chemicals using Reconstructed Human Cornea-like Epithelial (RhCE) Tissue Model

Published on: August 23, 2015

Adverse reactions to cosmetics.

A Dogra¹, Y C Minocha, S Kaur

¹Dept. of Dermatology, Dayanand Medical College & Hospital, Ludhiana, Punjab. samodagra@satyam.net.in

Indian Journal of Dermatology, Venereology and Leprology

|July 24, 2007

Summary

Cosmetic adverse reactions, including contact dermatitis, can manifest in various ways. Hair dyes, lipsticks, and shaving creams were identified as common culprits in a study of 50 patients.

Area of Science:

Dermatology
Cosmetic Science
Allergology

Background:

Adverse reactions to cosmetics are a significant cause of contact dermatitis.
Manifestations include allergic dermatitis, photodermatitis, irritant dermatitis, urticaria, and pigmentary changes.
Identifying causative agents is crucial for patient management and prevention.

Purpose of the Study:

To assess the role of commonly used cosmetics in causing adverse reactions.
To determine the incidence of contact allergic dermatitis from personal cosmetics.
To evaluate the utility of patch testing for cosmetic ingredients.

Main Methods:

A study involving 50 patients experiencing adverse cosmetic reactions.
Clinical assessment of dermatological presentations.

Related Experiment Videos

Last Updated: Jul 13, 2026

Eye Irritation Test (EIT) for Hazard Identification of Eye Irritating Chemicals using Reconstructed Human Cornea-like Epithelial (RhCE) Tissue Model

Eye Irritation Test (EIT) for Hazard Identification of Eye Irritating Chemicals using Reconstructed Human Cornea-like Epithelial (RhCE) Tissue Model

Published on: August 23, 2015

Patch testing with basic cosmetic ingredients where a causal link was suspected.

Main Results:

Hair dyes, lipsticks, and shaving creams were found to be frequent causes of adverse reactions.
The overall incidence of contact allergic dermatitis was 3.3% when using patients' own cosmetics.
Patch testing confirmed positive reactions to specific ingredients in some cases.

Conclusions:

Commonly used cosmetics, particularly hair dyes, lipsticks, and shaving creams, can trigger significant adverse reactions.
Clearer labeling of cosmetic ingredients is recommended to aid dermatologists and patients in identifying allergens.
Patch testing remains a valuable tool for diagnosing cosmetic-induced contact dermatitis.