Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Systemic sclerosis treated with dexamethasone pulse.

R Gupta1

  • 1Dept. of Dermato-Venereology, Vidyasagar Institute of Mental Health & Neuro Sciences, New Delhi. dr_ramji@yahoo.com

Indian Journal of Dermatology, Venereology and Leprology
|July 24, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Management of congenital lobar emphysema with endobronchial intubation and controlled ventilation.

Anesthesia and analgesia·1998
Same author

An unusual choledochal cyst.

Journal of gastroenterology and hepatology·1998
Same author

The single-copy gene encoding high-mobility-group protein HMG-I/Y from pea contains a single intron and is expressed in all organs.

Plant molecular biology·1998
Same author

Functions of SH2 and SH3 domains.

Current topics in microbiology and immunology·1997
Same author

Growth inhibition of B-cell precursor acute lymphoblastic leukemia cell lines by monocytes: a role for prostaglandin E2.

Leukemia research·1997
Same author

Coronary heart disease in India.

Circulation·1997
Same journal

Severe combined immunodeficiency (SCID) with pigmentary mosaicism: A coincidental occurrence in a child.

Indian journal of dermatology, venereology and leprology·2026
Same journal

Agminated multifocal eruptive lobular capillary haemangiomas - An uncommon presentation.

Indian journal of dermatology, venereology and leprology·2026
Same journal

Patch testing in India: Are we missing clinically relevant allergens?

Indian journal of dermatology, venereology and leprology·2026
Same journal

Double-loading technique for improved suspension retention on the recipient site in non-cultured epidermal cell suspension (NCES).

Indian journal of dermatology, venereology and leprology·2026
Same journal

Late-onset metastatic melanoma arising from a medium-sized congenital melanocytic naevus.

Indian journal of dermatology, venereology and leprology·2026
Same journal

Custom-compounded glycine-proline jelly for ulcers in prolidase deficiency.

Indian journal of dermatology, venereology and leprology·2026
See all related articles

Dexamethasone treatment showed significant improvement in a patient with progressive systemic sclerosis. Intravenous dexamethasone therapy reversed clinical manifestations over 21 months.

Area of Science:

  • Rheumatology
  • Endocrinology
  • Pharmacology

Background:

  • Systemic sclerosis is a chronic autoimmune disease characterized by progressive fibrosis.
  • The condition often leads to significant morbidity and mortality, with limited effective treatment options.
  • This case study focuses on a patient with long-standing, progressive systemic sclerosis refractory to conventional therapies.

Purpose of the Study:

  • To evaluate the efficacy of intravenous dexamethasone in managing progressive systemic sclerosis.
  • To report the clinical outcomes of a novel dexamethasone treatment regimen in a treatment-resistant patient.

Main Methods:

  • A 52-year-old female patient with an 8-year history of progressive systemic sclerosis was treated.
  • Treatment involved monthly intravenous administration of 100 mg dexamethasone in 500 ml of 5% glucose on 3 consecutive days.

Related Experiment Videos

  • Clinical manifestations were monitored over a 21-month period.

    • Main Results:

    • The patient experienced a remarkable reversal of all clinical manifestations of systemic sclerosis.
    • Significant improvement was observed following the 21-month treatment course.
    • No adverse events were mentioned, suggesting a potentially favorable safety profile in this case.

    Conclusions:

    • Intravenous dexamethasone therapy may represent a promising treatment option for severe, progressive systemic sclerosis.
    • Further research is warranted to confirm these findings in a larger cohort.
    • This case highlights the potential of corticosteroids in managing refractory systemic sclerosis.