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Fever due to levamisole.

R Gupta1, S Gupta

  • 1Vidyasagar Institute of Mental Health and Neurosciences, Nehru Nagar, New Delhi-110014. dr_ramji@yahoo.com

Indian Journal of Dermatology, Venereology and Leprology
|July 24, 2007
PubMed
Summary
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Levamisole rarely causes fever, but this case shows a clear link. A woman experienced recurrent fevers after taking levamisole, confirmed by re-exposure tests.

Area of Science:

  • Pharmacology
  • Toxicology
  • Clinical Medicine

Background:

  • Levamisole is an anthelmintic and immunomodulator.
  • Adverse drug reactions to levamisole are uncommon.
  • Fever is not a commonly recognized side effect of levamisole.

Purpose of the Study:

  • To report a rare case of levamisole-induced fever.
  • To highlight the potential for fever as an adverse drug reaction to levamisole.
  • To document the diagnostic process for drug-induced fever.

Main Methods:

  • Case report of a 26-year-old woman.
  • Detailed clinical history including drug exposure.
  • Provocation testing with levamisole to confirm causality.

Related Experiment Videos

Main Results:

  • The patient developed fever 4-12 hours after levamisole ingestion.
  • Symptoms resolved upon discontinuation of the drug.
  • Repeated provocation tests confirmed the association between levamisole and fever.

Conclusions:

  • Levamisole can, in rare instances, cause fever.
  • Clinicians should consider levamisole as a potential cause of fever in patients with relevant exposure.
  • Provocation testing is a valuable tool for diagnosing drug-induced fever.