Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Skin Cancer01:30

Skin Cancer

5.6K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
5.6K
The Intrinsic Apoptotic Pathway01:31

The Intrinsic Apoptotic Pathway

8.1K
Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
8.1K
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

5.1K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
5.1K
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

8.7K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
8.7K
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

15.7K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
15.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exploring AI as a Diagnostic Tool in Medical Imaging for Dermatopathological Diseases.

Indian journal of dermatology·2026
Same author

Epidermolysis Bullosa Acquisita.

Indian journal of dermatology, venereology and leprology·2017
Same author

Coloenteric fistula in a young patient with recurrent diverticulitis: A case report and review of the literature.

The Netherlands journal of medicine·2016
Same author

Reliability of specific finger dermatoglyphic patterns and their association with dental caries.

General dentistry·2014
Same author

Comparative assessment of the efficacy and safety of sertaconazole (2%) cream versus terbinafine cream (1%) versus luliconazole (1%) cream in patients with dermatophytoses: a pilot study.

Indian journal of dermatology·2013
Same author

Epithelioid hemangioendothelioma: a rare vascular tumor.

Indian journal of dermatology·2012
Same journal

Severe combined immunodeficiency (SCID) with pigmentary mosaicism: A coincidental occurrence in a child.

Indian journal of dermatology, venereology and leprology·2026
Same journal

Agminated multifocal eruptive lobular capillary haemangiomas - An uncommon presentation.

Indian journal of dermatology, venereology and leprology·2026
Same journal

Patch testing in India: Are we missing clinically relevant allergens?

Indian journal of dermatology, venereology and leprology·2026
Same journal

Double-loading technique for improved suspension retention on the recipient site in non-cultured epidermal cell suspension (NCES).

Indian journal of dermatology, venereology and leprology·2026
Same journal

Late-onset metastatic melanoma arising from a medium-sized congenital melanocytic naevus.

Indian journal of dermatology, venereology and leprology·2026
Same journal

Custom-compounded glycine-proline jelly for ulcers in prolidase deficiency.

Indian journal of dermatology, venereology and leprology·2026
See all related articles

Related Experiment Video

Updated: Jan 2, 2026

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
09:08

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

6.1K

Primary cutaneous B cell lymphoma.

I Bhat1, C Janaki, G Sentamilselvi

  • 1Department of Dermatology, Madras Medical College, Chennai-600003.

Indian Journal of Dermatology, Venereology and Leprology
|July 24, 2007
PubMed
Summary
This summary is machine-generated.

This study reports a rare case of primary cutaneous B cell lymphoma in a 54-year-old man. The patient showed a leonine facies and skin tumors, responding well to chemotherapy.

More Related Videos

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

11.6K
Cell Population Analyses During Skin Carcinogenesis
06:53

Cell Population Analyses During Skin Carcinogenesis

Published on: August 21, 2013

12.9K

Related Experiment Videos

Last Updated: Jan 2, 2026

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
09:08

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

6.1K
Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

11.6K
Cell Population Analyses During Skin Carcinogenesis
06:53

Cell Population Analyses During Skin Carcinogenesis

Published on: August 21, 2013

12.9K

Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Primary cutaneous B cell lymphoma (PCBCL) is a rare type of non-Hodgkin lymphoma.
  • PCBCL can present with diverse clinical manifestations, including tumors on sun-exposed skin.
  • Leonine facies is an uncommon but distinctive feature that can be associated with certain lymphomas.

Purpose of the Study:

  • To report a unique case of primary cutaneous B cell lymphoma presenting with leonine facies.
  • To highlight the diagnostic challenges and histopathological features of this rare condition.
  • To demonstrate the therapeutic efficacy of chemotherapy in this specific presentation.

Main Methods:

  • Clinical presentation and occupational history of the patient were documented.
  • Diagnostic investigations included histopathological examination of skin tumors.
  • Treatment involved a standard chemotherapy regimen.

Main Results:

  • The patient, a road layer, presented with a leonine facies and multiple cutaneous tumors.
  • Histopathology confirmed primary cutaneous B cell lymphoma with distinctive features.
  • Chemotherapy resulted in a significant and positive therapeutic response.

Conclusions:

  • Primary cutaneous B cell lymphoma can present with unusual facial disfigurement (leonine facies).
  • Accurate histopathological diagnosis is crucial for appropriate management.
  • Chemotherapy remains an effective treatment modality for this condition, leading to good outcomes.