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In vitro activity of cefpirome: a new fourth generation cephalosporin

A Chaudhury1

  • 1Department of Microbiology, Sri Venkateswara Institute of Medical Sciences, Tirupati - 517 507, AP, India.

Indian Journal of Medical Microbiology
|July 24, 2007
PubMed

Insights

Cefpirome (Cpo) efficacy was evaluated against 516 bacterial isolates in India. Cefpirome showed comparable activity to other cephalosporins, suggesting potential use in mixed infections.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Clinical Pharmacy

Background:

  • Antibiotic resistance is a growing global concern.
  • Cephalosporins are widely used antibiotics.
  • Evaluating new and existing antibiotics in local settings is crucial.

Purpose of the Study:

  • To determine the in vitro efficacy of cefpirome (Cpo) in an Indian tertiary care hospital.
  • To compare cefpirome's activity against common bacterial pathogens with other cephalosporins.
  • To assess the potential role of cefpirome in empirical therapy for mixed infections.

Main Methods:

  • A total of 516 bacterial isolates from various clinical specimens were tested.
  • Antibacterial activity was assessed using the Kirby Bauer technique.
  • Cefpirome was compared against cefazolin (Cz), cefuroxime (Cu), and cefotaxime (Ce).

Main Results:

  • Cefpirome demonstrated resistance rates of 54.2% in Gram-positive organisms and 66.0% in Enterobacteriaceae.
  • Resistance rates for cefpirome were comparable to cefazolin for Gram-positives and cefotaxime for Gram-negatives.
  • Minimum inhibitory concentrations (MICs) for resistant strains ranged from >16 mg/L to >256 mg/L.

Conclusions:

  • Cefpirome did not exhibit superior activity against the studied bacterial isolates.
  • Its activity profile suggests potential utility in treating mixed Gram-positive and Gram-negative infections.
  • Further studies may be warranted to confirm its role in empirical treatment strategies.

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