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Robust gammadelta+ T cell expansion in infants immunized at birth with BCG vaccine
T N Mazzola1, M T N Da Silva, Y M F Moreno
1Center of Investigation in Pediatrics, Pediatrics Department, State University of Campinas Medical School, Campinas, São Paulo, Brazil. tanmazzola@yahoo.com.br
Abstract:
Cell-mediated immune responses to BCG vaccine were evaluated in 7-month-old infants vaccinated with intradermal combined BCG and Hepatitis B or intradermal BCG and intramuscular Hepatitis B at birth. Peripheral blood mononuclear cell cultures from both groups showed CD4(+), CD8(+) and remarkable gammadelta(+) T cell BCG-specific proliferation, without significant differences. Also, IL-10, IL-12, IFN-gamma and TNF-alpha concentrations in culture supernatants, measured by ELISA, were similar. The results suggested that the combined BCG and Hepatitis B vaccine was as immunogenic as BCG separated from Hepatitis B vaccine.
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