Related Experiment Video
Updated: Jul 20, 2026
08:04
Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro
Published on: March 18, 2014
Photodynamic therapy with chlorins for diffuse malignant mesothelioma: initial clinical results
H B Ris1, H J Altermatt, R Inderbitzi
1Department of Thoracic and Cardiovascular Surgery, University of Bern, Switzerland.
British Journal of Cancer
|December 1, 1991
Summary
Intraoperative photodynamic therapy using meso-tetra-(hydroxyphenyl)-chlorin (mTHPC-PDT) showed promising tumoricidal effects for diffuse malignant mesothelioma. Further evaluation is warranted in suitable patients after surgical resection.
Area of Science:
- Oncology
- Photodynamic Therapy
- Surgical Oncology
Background:
- Diffuse malignant mesothelioma presents a significant therapeutic challenge.
- Intraoperative therapies are being explored to improve outcomes for mesothelioma patients.
Purpose of the Study:
- To evaluate the efficacy and safety of intraoperative photodynamic therapy (mTHPC-PDT) for diffuse malignant mesothelioma.
- To optimize mTHPC-PDT parameters for maximal tumoricidal effect.
Main Methods:
- Four patients with diffuse malignant mesothelioma underwent mTHPC-PDT after surgical tumor resection.
- Preliminary procedures were conducted to determine optimal mTHPC dose, light dose, and interval.
- Tumoricidal effect was assessed based on tumor infarction depth and histological changes.
Main Results:
- A dose of 0.3 mg/kg mTHPC activated after 48 hours with 10 J/cm² laser light achieved 10 mm tumor infarction via vessel necrosis.
- mTHPC concentration was significantly higher in tumor tissue compared to normal tissue.
- Mild, dose-dependent skin photosensitivity was observed 3-10 days post-administration.
Conclusions:
- Intraoperative mTHPC-PDT demonstrated a tumoricidal effect in diffuse malignant mesothelioma.
- The treatment warrants further investigation in carefully selected, good-risk patients undergoing surgical resection.
