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SAP discovery: the sword edges--beneficial and harmful
Shigemasa Sawada1, Masami Takei, Tetsuyosi Ishiwata
1Department of Rheumatology and Hematology, Nihon University Nerima Hikarigaoka Hospital, Tokyo, Japan. sswd98@med.nihon-u.ac.jp
Abstract:
We cloned the SLAM associated protein (SAP) gene in 1995. In 1998, it was discovered that the SAP gene was defective in patients with X-linked lymphoproliferative disease. Subsequently, details on the key role of life-long immune memory (vaccination) and of life-long autoantibody production in patients suffering from autoimmune disease have been revealed. In this paper, we discuss the dual nature of SAP in humans: its beneficial effect on life-long immune memory (vaccination) and its harmful effect on life-long autoantibody production.
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