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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
The Early Endosome: Endocytosis of Transferrin01:28

The Early Endosome: Endocytosis of Transferrin

Essential proteins such as insulin or low-density lipoprotein (LDL) and micronutrients such as iron enter a eukaryotic cell through receptor-mediated endocytosis. Subsequently, the early endosomes fuse with the vesicles containing such receptor-ligand complexes and play a vital role in sorting the incoming ligands and receptors. While the ligands are either degraded inside the vesicle or released into the cytosol, their receptors are returned to the plasma membrane for further rounds of...
Graves' Disease I: Introduction01:28

Graves' Disease I: Introduction

Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Translation01:31

Translation

Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life

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Related Experiment Video

Updated: Jul 13, 2026

Ferritinophagy: Assessing the Selective Degradation of Iron by Autophagy in Human Fibroblasts
09:21

Ferritinophagy: Assessing the Selective Degradation of Iron by Autophagy in Human Fibroblasts

Published on: February 23, 2024

Ferritin in autoimmune diseases.

Gisele Zandman-Goddard1, Yehuda Shoenfeld

  • 1Department of Medicine C, Wolfson Medical Center, Israel.

Autoimmunity Reviews
|July 24, 2007
PubMed
Summary

Ferritin sequesters iron, preventing toxicity. This review explores ferritin

Area of Science:

  • Biochemistry
  • Cell Biology
  • Immunology

Background:

  • Iron is vital but can be toxic; ferritin stores iron safely.
  • Ferritin comprises H and L subunits, with expression tightly regulated.
  • Genetic mutations cause ferritin disorders; elevated ferritin links to inflammation and disease.

Purpose of the Study:

  • To review ferritin structure and function.
  • To discuss hyperferritinemia in various disease states.
  • To explore the role of ferritin in autoimmune diseases.

Main Methods:

  • Literature review of ferritin structure, function, and regulation.
  • Analysis of hyperferritinemia associations with infections, malignancies, and inflammatory conditions.
  • Examination of ferritin's role in autoimmune diseases.

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Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

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Last Updated: Jul 13, 2026

Ferritinophagy: Assessing the Selective Degradation of Iron by Autophagy in Human Fibroblasts
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Ferritinophagy: Assessing the Selective Degradation of Iron by Autophagy in Human Fibroblasts

Published on: February 23, 2024

Assessing Iron Deposition in the Brains of 5xFAD Mice by Perls'/DAB Staining
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Assessing Iron Deposition in the Brains of 5xFAD Mice by Perls'/DAB Staining

Published on: May 23, 2025

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
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Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

Main Results:

  • Ferritin's dual role in iron homeostasis and cellular protection.
  • Hyperferritinemia is a marker for inflammation, infection, and cancer.
  • Limited research exists on ferritin in many autoimmune conditions.

Conclusions:

  • Ferritin is crucial for iron metabolism and cellular defense.
  • Hyperferritinemia warrants further investigation in autoimmune contexts.
  • Understanding ferritin's role may offer new diagnostic or therapeutic avenues.