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Related Experiment Video

Updated: Jul 13, 2026

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

Hyperhomocysteinemia, inflammation and autoimmunity.

Pietro Enea Lazzerini¹, Pier Leopoldo Capecchi, Enrico Selvi

¹Department of Clinical Medicine and Immunological Sciences, Division of Clinical Immunology, University of Siena, Italy. pietroenea@yahoo.it

Autoimmunity Reviews

|July 24, 2007

Summary

High homocysteine (Hcy) levels are linked to vascular disease. In autoimmune diseases (AD), Hcy may worsen cardiovascular issues and trigger autoimmune responses, requiring further study.

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Area of Science:

Cardiovascular Medicine
Immunology
Metabolic Disorders

Background:

Hyperhomocysteinemia is a known risk factor for vascular diseases in the general population.
Cardiovascular involvement is frequently advanced in patients with autoimmune diseases (AD), where hyperhomocysteinemia is common.

Purpose of the Study:

To investigate homocysteine (Hcy) as a risk factor for cardiovascular disease in AD patients.
To explore the bidirectional relationship between Hcy and immuno-inflammatory activation in AD.

Main Methods:

Literature review and analysis of existing data on hyperhomocysteinemia and autoimmune diseases.
Investigating the pathogenetic implications of Hcy in AD, including its pro-inflammatory and immuno-stimulating effects.

Main Results:

A bidirectional link exists between Hcy and immuno-inflammatory activation in AD.
Hcy may contribute to cardiovascular damage and trigger autoimmune reactions by forming neoantigens.
These effects are potentially relevant in rheumatoid arthritis and inflammatory bowel disease.

Conclusions:

Hyperhomocysteinemia plays a complex role in autoimmune diseases, potentially exacerbating cardiovascular damage and initiating autoimmune responses.
Further research is needed to fully elucidate the clinical significance of these findings.