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Strong poison revisited.

Roger C Prince1, Jürgen Gailer, Diane E Gunson

  • 1ExxonMobil Biomedical Sciences Inc., 1545 Route 22 East, Annandale, NJ 08801, USA. roger.c.prince@exxonmobile.com

Journal of Inorganic Biochemistry
|July 24, 2007
PubMed
Summary
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Chronic exposure to arsenic and mercury can lead to functional selenium deficiency. This occurs because selenium interacts with these toxic metals, making them less harmful but depleting available selenium.

Area of Science:

  • Biochemistry
  • Toxicology
  • Environmental Health

Background:

  • Selenium, particularly as selenocysteine, is vital for protein function and non-enzymatic biochemistry.
  • Inorganic selenium, arsenic, and mercury can interact under physiological conditions.

Purpose of the Study:

  • To review the interactions between inorganic selenium, arsenic, and mercury.
  • To investigate these interactions in the presence of glutathione under physiological conditions.
  • To explore the implications of these interactions for chronic arsenic and mercury exposure.

Main Methods:

  • Literature review focusing on the chemical interactions of selenium, arsenic, and mercury.
  • Analysis of biochemical pathways involving glutathione and these elements.

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Main Results:

  • Inorganic selenium, arsenic, and mercury interact under physiological conditions, facilitated by glutathione.
  • These interactions reduce the availability of arsenic and mercury for toxic reactions.
  • A consequence of these interactions is the potential for functional selenium deficiency.

Conclusions:

  • The interaction chemistry between selenium, arsenic, and mercury is significant for detoxification.
  • Chronic exposure to arsenic and/or mercury is likely to result in functional selenium deficiency due to these interactions.