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[Behavior of thyroid function following massive intestinal resection. Experimental study].

J C Martín del Olmo1, J Clement del Río, M Díez González

  • 1Servicio de Cirugía General, Hospital Comarcal de Medina del Campo, Valladolid.

Nutricion Hospitalaria
|July 1, 1991
PubMed
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This study investigated thyroid function in minipigs after intestinal resection, establishing a short bowel syndrome model. Results indicate animals remain euthyroid, though transient thyroid hormone oscillations suggest enterohepatic circulation changes during diarrhea.

Area of Science:

  • Endocrinology
  • Gastroenterology
  • Surgical Research

Background:

  • Massive intestinal resection can lead to short bowel syndrome, impacting nutrient absorption and potentially affecting hormonal regulation.
  • Thyroid function is crucial for metabolic processes, and its interplay with gastrointestinal function requires further investigation.

Purpose of the Study:

  • To investigate the behavior of thyroid function in an experimental model of short bowel syndrome following massive intestinal resection.
  • To analyze changes in thyroxine (T4), triiodothyronine (T3), and thyroid-stimulating hormone (TSH) levels over time.

Main Methods:

  • An experimental model of short bowel syndrome was created in two groups of seven minipigs each.
  • Radioimmunoassay (RIA) was used to measure T4, T3, and TSH levels at four time points: basal, immediately post-resection, two weeks post-resection, and six months post-resection.

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Main Results:

  • Animals with established short bowel syndrome maintained a euthyroid state.
  • Transient oscillations in T4 levels at two weeks (R3) and T3 levels immediately post-resection (R2) were observed.
  • These oscillations suggest potential alterations in the enterohepatic circulation of thyroid hormones during the acute diarrheal phase.

Conclusions:

  • Short bowel syndrome in this minipig model does not lead to a persistent hypothyroid or hyperthyroid state.
  • Acute diarrheal states following intestinal resection may transiently affect thyroid hormone levels via enterohepatic circulation disruptions.