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Real-Time Polymerase Chain Reaction-Based Detection and Quantification of Hepatitis B Virus DNA
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Hepatitis B and C virus coinfection in The TREAT Asia HIV Observational Database

Jialun Zhou1, Gregory J Dore, Fujie Zhang

  • 1National Centre in HIV Epidemiology and Clinical Research, The University of New South Wales, Sydney, Australia.

Journal of Gastroenterology and Hepatology
|July 25, 2007
PubMed

Insights

Hepatitis B (HBV) and C (HCV) coinfection with HIV affects approximately 10% of patients in the Asia-Pacific region. Coinfection did not significantly impact antiretroviral therapy response but was linked to elevated liver enzymes.

Area of Science:

  • Infectious Diseases
  • Hepatology
  • Virology

Background:

  • Limited data exists on hepatitis B virus (HBV) and hepatitis C virus (HCV) coinfection in HIV patients from the Asia-Pacific region.
  • Previous studies primarily focused on Western populations.

Purpose of the Study:

  • To determine the prevalence of HBV and HCV coinfection among HIV patients in the Asia-Pacific.
  • To evaluate the impact of coinfection on antiretroviral therapy (ART) response and mortality.

Main Methods:

  • Utilized data from The TREAT Asia HIV Observational Database (TAHOD).
  • Included patients tested for HBV surface antigen (HBsAg) or HCV antibody.
  • Defined coinfection as any positive test for HBV or HCV.

Main Results:

  • Prevalence of HBV and HCV coinfection was approximately 10% in the TAHOD cohort.
  • Coinfection showed a non-significant trend towards lower CD4 count increase post-ART initiation.
  • Neither HBV nor HCV coinfection was independently associated with increased mortality after covariate adjustment.
  • Both HBV and HCV were independently associated with elevated alanine aminotransferase (ALT) levels.

Conclusions:

  • The impact of HBV and HCV coinfection on ART response and HIV progression in this Asian cohort mirrors findings from Western studies.
  • Longer-term monitoring is crucial to understand the full impact of hepatitis coinfection on HIV and liver disease outcomes.
Abstract

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