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Antibodies to platelet-activating factor (PAF) inhibit PAF-induced platelet aggregation
M A Smal1, S J Cooney, B A Baldo
1Kolling Institute of Medical Research, Royal North Shore Hospital, St. Leonards, New South Wales, Australia.
Journal of Lipid Mediators
|November 1, 1991
Abstract:
Platelet-activating factor (PAF) is the most potent platelet agonist known. PAF-induced platelet aggregation was blocked by pre-incubation of PAF with the immunoglobulin fraction from sheep or rabbit anti-PAF anti-serum. Inhibition was specific for PAF and was dependent upon immunoglobulin and PAF concentrations. Antibody-mediated inhibition of PAF-activity may be a valuable method for studying the biological effects of PAF in some systems.