Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inhibitors of Bacterial DNA Synthesis01:28

Inhibitors of Bacterial DNA Synthesis

Bacterial pathogens depend on precise and efficient DNA replication to sustain infection. Two type II topoisomerases—DNA gyrase and topoisomerase IV—are critical to this process, as they resolve DNA supercoiling and unlink chromosomes during replication. Fluoroquinolones, synthetic derivatives of quinolones, exploit this mechanism by stabilizing the transient DNA–enzyme cleavage complex, preventing strand religation, and causing lethal double-strand breaks. These antibiotics are selectively...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exploring the feasibility of modeling next-day fatigue and sleepiness using digital sleep tracker data in neurodegenerative and immune-mediated inflammatory diseases.

Frontiers in digital health·2026
Same author

Interferon-α as a precision medicine tool in Sjögren's disease: a cohort and experimental medicine study.

The Lancet. Rheumatology·2026
Same author

Can real-world measures of activity, sleep, and cardiorespiratory function stratify Sjogren's disease participants with persistent fatigue? Insights from the BRC tools study.

EULAR rheumatology open·2026
Same author

Technology Acceptance of 2 mHealth Apps During an Observational Technology Evaluation Study: Qualitative Results of a Mixed Methods Study.

JMIR human factors·2026
Same author

IDEA-FAST clinical study protocol: Identifying digital end-points of fatigue, sleep quality and daytime sleepiness in N = 2000.

Digital health·2026
Same author

The SjD Map: an interactive pathway tour into Sjögren's disease signalling mechanisms.

NPJ systems biology and applications·2026

Related Experiment Video

Updated: Jul 13, 2026

A Passive Ankle Dorsiflexion Testing System for an In Vivo Model of Overuse-induced Tendinopathy
04:37

A Passive Ankle Dorsiflexion Testing System for an In Vivo Model of Overuse-induced Tendinopathy

Published on: March 1, 2024

Fluoroquinolone-associated tendinopathy: a case report.

Wan-Fai Ng1, Michael Naughton

  • 1Department of Rheumatology, Ealing Hospital NHS Trust, Ealing, Southall, UB1 3UJ UK. wan-fai.ng@ncl.ac.uk.

Journal of Medical Case Reports
|July 25, 2007
PubMed
Summary

Fluoroquinolone antibiotics, like ciprofloxacin, can cause tendinopathy, a serious tendon injury. This adverse drug reaction is often unrecognized by medical professionals, potentially leading to delayed diagnosis and treatment.

More Related Videos

A Standardized Acupotomy Protocol For The Treatment of Tenosynovitis of Hand Flexor Tendons In Human Patients
07:05

A Standardized Acupotomy Protocol For The Treatment of Tenosynovitis of Hand Flexor Tendons In Human Patients

Published on: May 26, 2026

Related Experiment Videos

Last Updated: Jul 13, 2026

A Passive Ankle Dorsiflexion Testing System for an In Vivo Model of Overuse-induced Tendinopathy
04:37

A Passive Ankle Dorsiflexion Testing System for an In Vivo Model of Overuse-induced Tendinopathy

Published on: March 1, 2024

A Standardized Acupotomy Protocol For The Treatment of Tenosynovitis of Hand Flexor Tendons In Human Patients
07:05

A Standardized Acupotomy Protocol For The Treatment of Tenosynovitis of Hand Flexor Tendons In Human Patients

Published on: May 26, 2026

Area of Science:

  • Pharmacology
  • Orthopedics
  • Drug Safety

Background:

  • Fluoroquinolone antibiotics are widely prescribed.
  • Fluoroquinolone-associated tendinopathy is a known but under-recognized adverse drug reaction.
  • This condition can lead to severe tendon damage, including rupture.

Purpose of the Study:

  • To highlight a case of ciprofloxacin-associated tendinopathy.
  • To emphasize the under-recognition of this adverse drug reaction among medical practitioners.
  • To increase awareness of fluoroquinolone-induced tendinopathy.

Main Methods:

  • Case report presentation.
  • Review of clinical presentation and management.
  • Discussion of fluoroquinolone pharmacology and toxicology.

Main Results:

  • A patient developed ciprofloxacin-associated tendinopathy.
  • The adverse drug reaction was initially unrecognized.
  • The patient received inappropriate initial medical advice.

Conclusions:

  • Fluoroquinolone-associated tendinopathy is an important, albeit uncommon, adverse drug reaction.
  • Increased awareness among healthcare providers is crucial for timely diagnosis and management.
  • Prompt recognition can prevent severe tendon complications and disability.