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Related Concept Videos

Thermosensation01:43

Thermosensation

Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
Increased Body Temperature01:25

Increased Body Temperature

A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in response to an infection or illness.
Thermoregulation01:26

Thermoregulation

The human body has a sophisticated thermoregulation system that employs negative feedback mechanisms to maintain an optimal core temperature. When the core temperature drops, peripheral and central thermoreceptors send signals to the hypothalamus, activating the heat-promoting center. This center triggers several responses aimed at increasing the core temperature. First, vasoconstriction reduces the flow of warm blood from internal organs to the skin so that the heat is not lost from the skin,...
Homeostatic Imbalances in Body Temperature01:19

Homeostatic Imbalances in Body Temperature

Hyperthermia occurs when the body's temperature becomes unusually high, often due to heat exposure, intense physical activity, or certain illnesses. This condition can create a dangerous cycle where elevated body temperature increases the metabolic rate, generating more heat and potentially leading to organ failure and brain damage. A severe form of hyperthermia, called heat stroke, can raise body temperature to life-threatening levels. Fever, on the other hand, is a controlled form of...
Regulation of Food Intake01:30

Regulation of Food Intake

Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
Body Temperature01:25

Body Temperature

The body's temperature, measured in degrees, is determined by the balance between heat production and dissipation to the surrounding environment. For instance, if exercising vigorously, the body will produce more heat, causing sweat and dissipating that heat. Despite extreme environmental conditions and physical exertion, the human temperature-control system maintains a constant core body temperature (the temperature of deep tissues, which are the tissues located beneath the skin and other...

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Related Experiment Video

Updated: Jul 13, 2026

Ex Vivo Release of Calcitonin Gene-Related Peptide from the Trigeminovascular System in Rodents
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Neuropeptides in hyperthermia.

Fred Nyberg1, Mathias Hallberg

  • 1Department of Pharmaceutical Biosciences, Division of Biological Research on Drug Dependence, Uppsala University, S-751 24 Uppsala, Sweden. Fred.Nyberg@farmbio.uu.se

Progress in Brain Research
|July 25, 2007
PubMed
Summary

Hyperthermia can cause brain damage by altering neurotransmitter systems. This review explores how neuropeptides like opioid peptides and tachykinins are involved in heat disorders and body temperature regulation.

Area of Science:

  • Neuroscience
  • Physiology
  • Biochemistry

Background:

  • Hyperthermia and heat stress are increasingly recognized as causes of brain damage.
  • Heat-induced changes in the central nervous system (CNS) affect neurotransmitter systems, influencing behavior.
  • Previous research indicates alterations in excitatory amino acid, monoaminergic, and peptidergic systems during hyperthermia.

Purpose of the Study:

  • To review current research on neuropeptides implicated in hyperthermia and heat-related disorders.
  • To focus on specific neuropeptide systems significantly affected by abnormal body temperature.
  • To elucidate the role of neuropeptides in body heat control and thermal regulation.

Main Methods:

  • Literature review of past and current research.

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  • Focus on neuropeptide systems including opioid peptides, tachykinins, calcitonin gene-related peptide (CGRP), and angiotensin peptides.
  • Analysis of neuropeptide involvement in both immediate and long-term consequences of thermal changes.

    • Main Results:

    • Neuropeptide systems, including opioid peptides, tachykinins, CGRP, and angiotensin, are affected by hyperthermia.
    • These neuropeptides play a role in the endogenous mechanisms of body temperature regulation.
    • Alterations in these peptidergic systems are observed during various thermal challenges.

    Conclusions:

    • Neuropeptides are critically involved in the central nervous system's response to heat stress and hyperthermia.
    • Understanding these peptidergic pathways is crucial for addressing heat-related neurological disorders.
    • Further research into neuropeptide function can offer insights into thermoregulation and its disruption.