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Related Experiment Video

Updated: Jul 13, 2026

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System

Published on: October 16, 2013

Comparative performance of two polyp detection systems on CT colonography.

J G Fletcher¹, Fargol Booya, Ronald M Summers

¹Department of Radiology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA.

AJR. American Journal of Roentgenology

|July 25, 2007

Summary

Two automatic polyp detection systems were evaluated for CT colonography. The NIH system showed higher sensitivity for large polyps, while the PEV tool had significantly fewer false positives.

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Last Updated: Jul 13, 2026

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System

Published on: October 16, 2013

Area of Science:

Medical imaging
Gastroenterology
Artificial intelligence in medicine

Background:

CT colonography (CTC) is a minimally invasive screening tool for colorectal cancer.
Automatic polyp detection (APD) systems aim to improve the accuracy and efficiency of CTC interpretation.
Evaluating the performance of existing APD systems is crucial for their clinical adoption.

Purpose of the Study:

To compare the sensitivity and false-positive rates of two APD systems, Polyp Enhanced Viewing (PEV) and the National Institutes of Health (NIH) CAD system.
To assess the performance of these systems in detecting polyps of different sizes during CTC.

Main Methods:

Two APD systems (PEV and NIH CAD) were evaluated using a cohort of 65 CTC examinations.
The cohort included 31 examinations with radiologist-confirmed true-positive lesions and 34 with false-positive lesions.
Lesion detection by APD systems was compared against a reference standard of colonoscopy performed within 7 days of CTC.

Main Results:

The NIH system demonstrated higher sensitivity for polyps ≥1 cm (96%) compared to the PEV tool (61%) (p=0.008).
No significant difference in sensitivity was found for medium-sized polyps (6-9 mm) between the systems (p=0.68).
The PEV tool generated significantly fewer false-positive detections per patient (1.18) than the NIH tool (5.20) (p<0.001).

Conclusions:

One APD system excels in sensitivity for larger polyps, while the other offers a lower false-positive rate.
Further prospective trials are warranted to investigate the clinical utility of APD systems in CTC interpretation.