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A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials

A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials

Published on: March 3, 2023

Observations on vancomycin use in U.S. hospitals.

Joseph A Paladino¹, Jenna L Sunderlin, Martin H Adelman

¹Clinical Outcomes Research, CPL Associates, LLC, Buffalo, NY 14226, USA.

American Journal of Health-System Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists

|July 25, 2007

Summary

Vancomycin is rarely restricted in U.S. hospitals and remains effective, with routine monitoring of serum concentrations. However, the increasing prevalence of methicillin-resistant Staphylococcus aureus (MRSA) requires ongoing attention.

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A Reference Broth Microdilution Method for Dalbavancin In Vitro Susceptibility Testing of Bacteria that Grow Aerobically

A Reference Broth Microdilution Method for Dalbavancin In Vitro Susceptibility Testing of Bacteria that Grow Aerobically

Published on: September 9, 2015

Area of Science:

Infectious Diseases
Pharmacology
Hospital Pharmacy Practice

Background:

Vancomycin is a critical antibiotic for treating serious gram-positive bacterial infections.
Understanding current vancomycin usage patterns and clinical outcomes is essential for optimizing patient care.
The rise of antibiotic resistance, particularly methicillin-resistant Staphylococcus aureus (MRSA), necessitates continuous evaluation of treatment strategies.

Purpose of the Study:

To assess current knowledge and policies regarding vancomycin use in U.S. hospitals.
To evaluate the clinical performance of vancomycin in hospitalized adult patients.
To examine trends in gram-positive bacterial susceptibility, including MRSA.

Main Methods:

A survey was distributed to hospital pharmacists across the U.S.
An observational study analyzed data from 200 hospitalized adults receiving intravenous vancomycin for at least 72 hours.
Hospital antibiograms were collected to determine gram-positive susceptibility patterns.

Main Results:

Vancomycin use was found to be rarely restricted.
Serum vancomycin concentrations were routinely monitored, with higher levels observed in teaching hospitals.
The overall clinical success rate was 82%, with a 6.5% incidence of adverse events, more frequent in teaching hospitals.
Staphylococcus aureus was identified in 52% of positive cultures, with 75% being MRSA.

Conclusions:

Vancomycin demonstrates continued effectiveness with infrequent adverse events and routine trough concentration monitoring.
The increasing prevalence of MRSA is a significant finding, highlighting the need for vigilant antibiotic stewardship.
Clinical outcomes did not significantly differ between teaching and non-teaching hospitals, despite variations in vancomycin dosing.