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Related Concept Videos

Antigen Presenting Cells01:22

Antigen Presenting Cells

The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Nervous Tissue: Neuron Types01:19

Nervous Tissue: Neuron Types

Neurons, the fundamental units of the nervous system, can be classified based on both their structural and functional characteristics.
Structurally, neurons are categorized into three main types: multipolar, bipolar, and unipolar (or pseudounipolar). Multipolar neurons, which are the most common type in the brain and spinal cord, as well as all motor neurons, possess multiple dendrites and a single axon.
Bipolar neurons, on the other hand, have one primary dendrite and one axon. They are...
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.

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Updated: Jul 13, 2026

An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets
09:09

An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets

Published on: April 18, 2016

Dendritic cells: nature and classification.

Katsuaki Sato1, Shigeharu Fujita

  • 1Laboratory for Dendritic Cell Immunobiology, Research Center for Allergy and Immunology, RIKEN Yokohama Institute, Kanagawa, Japan. katsuaki@rcai.riken.jp

Allergology International : Official Journal of the Japanese Society of Allergology
|July 25, 2007
PubMed
Summary

Dendritic cells (DCs), a type of antigen-presenting cell (APC), are crucial for initiating immune responses and maintaining tolerance. This review explores the diverse subsets and functions of DCs in immune regulation.

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Generation of Human Monocyte-derived Dendritic Cells from Whole Blood
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Generation of Human Monocyte-derived Dendritic Cells from Whole Blood

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Last Updated: Jul 13, 2026

An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets
09:09

An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets

Published on: April 18, 2016

A Simple and Efficient Method for Testing Immunomodulatory Agents for Generation of Tolerogenic Dendritic Cells from Human CD14+ Monocytes
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A Simple and Efficient Method for Testing Immunomodulatory Agents for Generation of Tolerogenic Dendritic Cells from Human CD14+ Monocytes

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Generation of Human Monocyte-derived Dendritic Cells from Whole Blood
07:35

Generation of Human Monocyte-derived Dendritic Cells from Whole Blood

Published on: December 24, 2016

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Dendritic cells (DCs) are key antigen-presenting cells (APCs) initiating adaptive immunity by stimulating naive T cells.
  • DCs are increasingly recognized for their roles in immunological tolerance, immune response regulation, and innate immunity surveillance.
  • The complex functions of DCs stem from their diverse subsets and adaptable nature.

Purpose of the Study:

  • To review recent advancements in understanding dendritic cell (DC) subsets.
  • To discuss the classification and functional heterogeneity of DCs.
  • To highlight the multifaceted roles of DCs in immune regulation.

Main Methods:

  • Literature review of recent studies on dendritic cells.
  • Analysis of research on DC heterogeneity and plasticity.
  • Synthesis of current knowledge on DC classification and function.

Main Results:

  • DCs possess a unique ability to stimulate naive T cells and initiate primary immune responses.
  • DCs are vital for inducing both central and peripheral immunological tolerance.
  • DCs regulate the specific types of T cell-mediated immune responses and act as sentinels against microbial invasion.

Conclusions:

  • The diverse functions of dendritic cells are attributed to their heterogeneous subsets and functional plasticity.
  • Understanding DC subsets and their classification is crucial for comprehending immune regulation.
  • DCs are central players in both immunity and tolerance, highlighting their complex immunological roles.