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A Pipeline to Characterize Structural Heart Defects in the Fetal Mouse
Published on: December 16, 2022
[Is antenatal diagnosis of coarctation of the aorta possible?]
B Stos1, J Le Bidois, L Fermont
1Service de cardiologie pédiatrique, Hôpital Necker-Enfants Malades, 149, rue de Sèvres, 75743 Paris cedex 15. bertrand.stos@nck.aphp.fr
Abstract:
Antenatal diagnosis of coarctation of the aorta is difficult but primordial because it reduces the mortality due to this malformation by early treatment of the neonate. Echocardiography allows identification of groups at high risk but does not predict with certainty the constitution of a coarctation after birth. The authors review their experience of 202 foetus at risk of coarctation. Of the 167 known live births, 19% finally developed a coarctation. The predictive factors of coarctation were early diagnosis in the second trimester of pregnancy, a ratio of pulmonary artery diameter to aortic diameter greater than 1.6, the presence of a left superior vena cava and bicuspid aortic valve, the diagnosis of which is more often postnatal but which enables prediction of coarctation with nearly 90% accuracy when ventricular asymmetry has been identified at an early stage. It is therefore important to look for these echocardiographic signs which are an aid to antenatal diagnosis of coarctation and better identify subjects at risk. In fact, the finding of ventriculo-arterial asymmetry alone leads to the taking of unnecessary precautions in 80% of cases and anguish to parents who end up with a baby with a normal heart.
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