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Updated: May 7, 2026

Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis
10:04

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Published on: May 1, 2015

Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets

Teru Hideshima1, Constantine Mitsiades, Giovanni Tonon

  • 1Jerome Lipper Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA.

Nature Reviews. Cancer
|July 25, 2007
PubMed

Insights

Multiple myeloma, a plasma cell cancer, involves genetic changes and bone marrow support. New targeted therapies offer hope against drug resistance and improve patient outcomes.

Area of Science:

  • Hematology
  • Oncology
  • Cancer Genomics

Background:

  • Multiple myeloma is a plasma cell malignancy with complex cytogenetic abnormalities.
  • The bone marrow microenvironment is crucial for myeloma cell growth and therapy resistance.

Purpose of the Study:

  • To review advancements in understanding multiple myeloma pathogenesis.
  • To highlight the role of novel targeted agents in overcoming drug resistance.
  • To discuss the impact of oncogenomic studies on prognostic classification and therapeutic targets.

Main Methods:

  • Review of recent oncogenomic studies.
  • Analysis of novel targeted agents in multiple myeloma treatment.
  • Examination of the bone marrow microenvironment's role.

Main Results:

  • Novel targeted agents show promise in overcoming drug resistance.
  • Oncogenomic studies are refining prognostic classification.
  • New therapeutic targets are being identified.

Conclusions:

  • Targeted therapies represent a significant advancement in multiple myeloma treatment.
  • Understanding molecular pathogenesis is key to improving patient outcomes.
  • Further research into therapeutic targets is warranted.

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