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Tumor models in drug development.

D P Griswold¹, S D Harrison

¹Southern Research Institute, Birmingham, Alabama.

Cancer Metastasis Reviews

|October 11, 1991

Summary

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This review examines the evolution of anticancer drug screening methods. Current practices are shifting towards developing selective drugs for solid tumors due to a lack of effective treatments.

Area of Science:

Oncology
Pharmacology
Drug Discovery

Background:

Anticancer drug screening has a long history.
Traditional screening methods have limitations in identifying effective treatments for solid tumors.

Purpose of the Study:

To review the historical development of anticancer drug screening.
To evaluate current screening practices and models.
To reflect on the shift towards developing histotype-selective anticancer drugs.

Main Methods:

Historical review of anticancer drug screening.
Analysis of changes in drug discovery emphasis.
Evaluation of current model tumor systems and screening practices.

Main Results:

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A significant shift in drug discovery has influenced anticancer screening.
New model tumor systems are being developed.
Emphasis is now on drugs selective for specific tumor histotypes, particularly solid tumors.

Conclusions:

The current approach to anticancer drug discovery and screening is experimental.
The success of this new direction in developing selective drugs for solid tumors remains to be determined.