Related Experiment Video
Updated: Aug 10, 2026
Generation of Microtumors Using 3D Human Biogel Culture System and Patient-derived Glioblastoma Cells for Kinomic Profiling and Drug Response Testing
Published on: June 9, 2016
Tumor models in drug development
1Southern Research Institute, Birmingham, Alabama.
Abstract:
In this short essay, we have taken the opportunity to review briefly the history of anticancer drug screening, consider the changes that have been made throughout that history, and reflect on the suitability of current screening practices and the models employed. A major change in emphasis in drug discovery has influenced the development and selection of new model tumor systems as well as screening practices. This new direction, a search for drugs that are selective for particular tumor histotypes, especially solid tumors, was stimulated by the paucity of drugs that have clinical solid tumor activity. The new approach to drug discovery and screening is in itself an experiment. Only time will tell if this approach is successful.
Insights
This review examines the evolution of anticancer drug screening methods. Current practices are shifting towards developing selective drugs for solid tumors due to a lack of effective treatments.
Area of Science:
- Oncology
- Pharmacology
- Drug Discovery
Background:
- Anticancer drug screening has a long history.
- Traditional screening methods have limitations in identifying effective treatments for solid tumors.
Purpose of the Study:
- To review the historical development of anticancer drug screening.
- To evaluate current screening practices and models.
- To reflect on the shift towards developing histotype-selective anticancer drugs.
Main Methods:
- Historical review of anticancer drug screening.
- Analysis of changes in drug discovery emphasis.
- Evaluation of current model tumor systems and screening practices.
Main Results:
- A significant shift in drug discovery has influenced anticancer screening.
- New model tumor systems are being developed.
- Emphasis is now on drugs selective for specific tumor histotypes, particularly solid tumors.
Conclusions:
- The current approach to anticancer drug discovery and screening is experimental.
- The success of this new direction in developing selective drugs for solid tumors remains to be determined.
More Related Videos
09:29Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies
Published on: September 30, 2016
13:19Quantifying Antibody-Dependent Cellular Cytotoxicity in a Tumor Spheroid Model: Application for Drug Discovery
Published on: April 26, 2024
Related Concept Videos
02:43Mouse Models of Cancer Study
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
02:43Mouse Models of Cancer Study
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...