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Updated: Jul 13, 2026

Born Normalization for Fluorescence Optical Projection Tomography for Whole Heart Imaging
Published on: June 2, 2009
A statistical approach to inverting the Born ratio
Damon Hyde1, Eric Miller, Dana H Brooks
1Electrical and Computer Engineering Department, Northeastern University, Boston, MA 02115, USA. dhyde@ece.neu.edu
Abstract:
We examine the problem of fluorescence molecular tomography using the normalized Born approximation, termed herein the Born ratio, from a statistical perspective. Experimentally verified noise models for received signals at the excitation and emission wavelengths are combined to generate a stochastic model for the Born ratio. This model is then utilized within a maximum likelihood framework to obtain an inverse solution based on a fixed point iteration. Results are presented for three experimental scenarios: phantom data with a homogeneous background, phantoms implanted within a small animal, and in vivo data using an exogenous probe.
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