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Experimental radiotherapy-induced enteritis: a probiotic interventional study
Journal of Digestive Diseases
|July 26, 2007
Summary
A novel probiotic mixture (Microflorana-F) reduced endotoxinemia and bacterial translocation in rats with radiation enteritis. This suggests probiotics may be a viable treatment for radiation-induced intestinal damage.
Area of Science:
- Gastroenterology
- Radiation Oncology
- Microbiology
Background:
- Acute radiation exposure significantly impacts the small intestine's regenerative epithelium and overall ecosystem.
- Radiation enteritis is characterized by increased endotoxinemia and bacterial translocation.
Purpose of the Study:
- To evaluate a novel probiotic formulation, Microflorana-F, in an experimental model of acute radiation enteritis.
- To assess the effects of the probiotic on endotoxinemia and bacterial translocation.
Main Methods:
- Male Wistar rats were divided into groups receiving a standard diet, active Microflorana-F, or heat-inactivated Microflorana-F.
- Rats underwent abdominal irradiation (20 Gy); sham-radiated rats served as controls.
- Samples from mesenteric lymph nodes, spleen, liver, blood, portal vein, and bile were cultured; endotoxinemia was measured.
Main Results:
- Early deaths were higher in rats fed standard food or inactivated probiotic.
- Active Microflorana-F supplementation significantly reduced endotoxin levels in irradiated rats (P < 0.05).
- The active probiotic significantly decreased bacterial contamination in mesenteric lymph nodes and portal blood samples.
Conclusions:
- Biologically active probiotic preparations can modulate the gut ecosystem.
- Probiotics show promise as a therapeutic and preventive strategy for radiation-induced enteritis.
