Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Experimental radiotherapy-induced enteritis: a probiotic interventional study.

Mg Seal1, Y Naito, R Barreto

  • 1SFJO and Laboratories, Paris, France.

Journal of Digestive Diseases
|July 26, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mitochondrial and redox dysfunction in post-menopause as risk factor of neurodegenerative disease: a pilot study testing the role of a validated Japanese functional food.

Journal of biological regulators and homeostatic agents·2020
Same author

Nonlinear fluctuating hydrodynamics with many conserved fields: The case of a three-dimensional anharmonic chain.

Physical review. E·2019
Same author

Current trends in etiology, prognosis and therapeutic aspects of Parkinson's disease: a review.

Acta bio-medica : Atenei Parmensis·2017
Same author

Mutation in the Sodium Channel Gene Corresponds With Phenotypic Resistance of Rhipicephalus sanguineus sensu lato (Acari: Ixodidae) to Pyrethroids.

Journal of medical entomology·2017
Same author

Neutrophil gelatinase-associated lipocalin is a biomarker of acute-on-chronic liver failure and prognosis in cirrhosis.

Journal of hepatology·2016
Same author

Gut microbiota in health and disease: an overview focused on metabolic inflammation.

Beneficial microbes·2015
Same journal

Retention of a Patency Capsule Shell in a Nonsteroidal Anti-Inflammatory Drug-Induced Small-Bowel Stricture, Detected and Retrieved by Balloon-Assisted Enteroscopy: Emphasizing the Importance of Confirming Capsule Excretion.

Journal of digestive diseases·2026
Same journal

Pancreatic Tuberculosis Complicated With Duodenal Bulb Fistula Mimics Walled-Off Necrosis: A Case Report.

Journal of digestive diseases·2026
Same journal

Comparison of Tacrolimus and Infliximab for Acute Severe Ulcerative Colitis in Hospitalized Adults: A Retrospective Study.

Journal of digestive diseases·2026
Same journal

Postoperative Clinical Features of High-Grade Squamous Intraepithelial Neoplasia Dominated by Cytological Atypia After Endoscopic Submucosal Dissection.

Journal of digestive diseases·2026
Same journal

Emerging Concepts in the Prevention and Treatment of Severe Acute Pancreatitis.

Journal of digestive diseases·2026
Same journal

Multidimensional Optimization of Small Bowel Capsule Endoscopy With Transcutaneous Electrical Acustimulation: A Randomized Controlled Trial.

Journal of digestive diseases·2026
See all related articles

A novel probiotic mixture (Microflorana-F) reduced endotoxinemia and bacterial translocation in rats with radiation enteritis. This suggests probiotics may be a viable treatment for radiation-induced intestinal damage.

Area of Science:

  • Gastroenterology
  • Radiation Oncology
  • Microbiology

Background:

  • Acute radiation exposure significantly impacts the small intestine's regenerative epithelium and overall ecosystem.
  • Radiation enteritis is characterized by increased endotoxinemia and bacterial translocation.

Purpose of the Study:

  • To evaluate a novel probiotic formulation, Microflorana-F, in an experimental model of acute radiation enteritis.
  • To assess the effects of the probiotic on endotoxinemia and bacterial translocation.

Main Methods:

  • Male Wistar rats were divided into groups receiving a standard diet, active Microflorana-F, or heat-inactivated Microflorana-F.
  • Rats underwent abdominal irradiation (20 Gy); sham-radiated rats served as controls.
  • Samples from mesenteric lymph nodes, spleen, liver, blood, portal vein, and bile were cultured; endotoxinemia was measured.

Related Experiment Videos

Main Results:

  • Early deaths were higher in rats fed standard food or inactivated probiotic.
  • Active Microflorana-F supplementation significantly reduced endotoxin levels in irradiated rats (P < 0.05).
  • The active probiotic significantly decreased bacterial contamination in mesenteric lymph nodes and portal blood samples.

Conclusions:

  • Biologically active probiotic preparations can modulate the gut ecosystem.
  • Probiotics show promise as a therapeutic and preventive strategy for radiation-induced enteritis.