Related Experiment Video
Updated: Jul 13, 2026

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study
Published on: August 15, 2025
A controlled prospective investigation of psychiatric comorbidity in temporal lobe epilepsy
Jana E Jones1, Brian Bell, Jason Fine
1Department of Neurology and Biostatistics, University of Wisconsin, Madison, Wisconsin 53792, USA. jejones@neurology.wisc.edu
Abstract:
Temporal lobe epilepsy patients (n = 48) and healthy controls (n = 69) underwent structured psychiatric interview at baseline and 4 years later to characterize the course of DSM-IV Axis I disorders. Adjusting for the influence of prior psychiatric history, epilepsy subjects exhibit significantly greater risk of interval episodes of Total Axis I Disorders and Mood Disorders, indicating a poorer prognosis for these comorbidities in the context of chronic temporal lobe epilepsy.

