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Updated: Jul 13, 2026
09:25
Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
Published on: October 14, 2016
Synovial sarcoma in children. A single centre experience
L Moreno Martín-Retortillo1, M M Andrés Moreno, A Cañete Nieto
1Paediatric Oncology Unit, Children's Hospital La Fe, Valencia, Spain. lucasmoreno@comv.es
Summary
Synovial sarcoma (SS) is a rare pediatric cancer. While surgery is key for resectable tumors, outcomes vary despite varied chemotherapy, highlighting the need for improved pediatric synovial sarcoma treatments.
Area of Science:
- Pediatric Oncology
- Surgical Oncology
- Medical Oncology
Background:
- Synovial sarcoma (SS) is a rare malignancy predominantly affecting adolescents.
- Surgical resection is the primary treatment for localized SS.
- The efficacy of adjuvant therapies like chemotherapy and radiotherapy remains unproven.
Observation:
- This report details four pediatric cases (ages 7-13) of synovial sarcoma affecting upper and lower limbs.
- All patients underwent satisfactory surgical resections.
- Diverse chemotherapy regimens were administered to the patients.
Findings:
- Outcomes varied significantly among the four patients despite similar surgical success.
- One patient is undergoing treatment for relapse.
- Two patients are currently disease-free, while one patient succumbed to metastatic disease.
Implications:
- The study underscores the challenges in treating pediatric synovial sarcoma, even with successful surgery.
- Prognostic factors such as metastatic disease and surgical completeness are critical.
- Further research into effective adjuvant therapies for pediatric SS is warranted.
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