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Updated: Jul 13, 2026

Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors
Published on: June 7, 2018
Assessment of cancer immunotherapy outcome in terms of the immune response time features
D Rodríguez-Pérez1, Oscar Sotolongo-Grau, Ramón Espinosa Riquelme
1Departamento de Física Matemática y de Fluidos, UNED, PO Box 60141, 28080 Madrid, Spain. daniel@dfmf.uned.es
Abstract:
A cytokine-based periodic immunotherapy treatment is included in a model of tumour growth with a delay. The effects of dose schedule are studied in the case of a weak immune system and a growing tumour. We find the existence of 'metastable' states (that may last for tens of years) induced by the treatment and also potentially adverse effects of the dosage frequency on the stabilization of the tumour. These two effects depend on the delay between the tumour growth and the immune system response, the cytokine dose burden, and other parameters considered in the model.
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