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Photodynamic therapy in dentistry.

K Konopka1, T Goslinski

  • 1Department of Microbiology, University of the Pacific, Arthur A. Dugoni School of Dentistry, San Francisco, CA, USA. kkonopka@pacific.edu

Journal of Dental Research
|July 27, 2007
PubMed
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Photodynamic therapy (PDT) uses light-activated dyes to create oxygen species that destroy diseased cells and microbes. This safe and effective treatment shows promise for various dental conditions, including infections and oral cancer.

Area of Science:

  • Biomedical Engineering
  • Photochemistry
  • Oral Medicine

Background:

  • Photodynamic therapy (PDT) utilizes photosensitizers activated by light to generate cytotoxic oxygen species.
  • PDT has demonstrated efficacy in treating oral conditions like cancer, infections, and pre-malignant lesions.
  • Photodynamic antimicrobial chemotherapy (PACT) is effective against a range of pathogens.

Purpose of the Study:

  • To explore the expanding applications of PDT in dentistry.
  • To highlight PDT's potential in managing oral biofilms and infections.
  • To discuss the safety profile and future directions of PDT in oral healthcare.

Main Methods:

  • Activation of photosensitizers with specific light wavelengths in the presence of oxygen.
  • Generation of reactive oxygen species (singlet oxygen, free radicals) to induce cell damage.

Related Experiment Videos

  • Application of PDT/PACT for treating oral cancer, infections, and diagnosing lesions.

    • Main Results:

    • PDT shows potential in treating oral leukoplakia, lichen planus, and head and neck cancer.
    • PACT is effective against bacterial, fungal, parasitic, and viral infections.
    • PDT offers a safe, non-genotoxic therapeutic option for oral conditions and biofilms.

    Conclusions:

    • PDT is a rapidly growing therapeutic modality in dentistry with diverse applications.
    • The oral cavity's accessibility makes it ideal for photodynamic antimicrobial chemotherapy (PACT).
    • Future research focuses on selective photosensitizers to preserve beneficial oral flora and prevent opportunistic infections.