Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Structural Joints: Synovial Joints

Structural Joints: Synovial Joints

Synovial joints are the most common type of joint in the body. A key structural characteristic for a synovial joint is the presence of a joint cavity. This fluid-filled space is where the articulating surfaces of the bones contact each other. Also, unlike fibrous or cartilaginous joints, the articulating bone surfaces at a synovial joint are not directly connected to each other with fibrous connective tissue or cartilage. This gives the bones of a synovial joint the ability to move smoothly...

Cell-matrix's Response to Mechanical Forces

Cell-matrix's Response to Mechanical Forces

In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue.
Anchoring junctions mechanically attach a cell to the...

Normal Strain under Axial Loading

Normal Strain under Axial Loading

Normal strain under axial loading is an important concept in the field of mechanics of materials. Axial loading implies the application of a force along the axis of a material, like a column or bar. This force can either compress or stretch the material. In the context of axial loading, normal strain is the deformation experienced by the material in the direction of the loading force. It's calculated as the change in length divided by the original length of the material. This unitless ratio...

Development of the Limb Synovial Joints

Development of the Limb Synovial Joints

Joints form during embryonic development in conjunction with the formation and growth of the associated bones. The embryonic tissue that gives rise to all bones, cartilage, and connective tissues of the body is called mesenchyme.
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Thyroid FNA cytology in Asian practice-Active surveillance for indeterminate thyroid nodules reduces overtreatment of thyroid carcinomas.

Cytopathology : official journal of the British Society for Clinical Cytology·2017

Same author

Prolonged matrix metalloproteinase-3 high expression after cyclic compressive load on human synovial cells in three-dimensional cultured tissue.

International journal of oral and maxillofacial surgery·2012

Same author

[The relationship between chemotherapy and multidrug resistance of lung cancer].

Zhongguo fei ai za zhi = Chinese journal of lung cancer·2010

Same author

Clonality of the parathyroid nodules with uremic parathyroid hyperplasia.

Pathology oncology research : POR·2008

Same author

Biomechanical properties of the condyle created by osteodistraction.

Journal of dental research·2008

Same author

Expression and cellular localization of calcitonin receptor: RT-PCR and in situ hybridization studies.

Cellular and molecular biology (Noisy-le-Grand, France)·2007

Search research articles

Related Experiment Video

Updated: Jul 13, 2026

A Friction Testing-Bioreactor Device for Study of Synovial Joint Biomechanics, Mechanobiology, and Physical Regulation

A Friction Testing-Bioreactor Device for Study of Synovial Joint Biomechanics, Mechanobiology, and Physical Regulation

Published on: June 2, 2022

Effects of compressive loading on human synovium-derived cells.

Y Muroi¹, K Kakudo, K Nakata

¹Second Department of Oral and Maxillofacial Surgery, Osaka Dental University, 1-5-17, Otemae, Chuo-ku, Osaka, 540-0008, Japan. ymuroi-osaka@umin.ac.jp

Journal of Dental Research

|July 27, 2007

Summary

Mechanical compression of temporomandibular joint (TMJ) synovial cells in vitro up-regulates inflammatory cytokines and matrix metalloproteinases (MMPs). This suggests mechanical stress may contribute to TMJ synovitis and degenerative changes in temporomandibular joint disease.

More Related Videos

A Pre-Clinical Model of Synovitis Using Ex vivo Human Synovial Tissue with Preserved Function and Architecture

A Pre-Clinical Model of Synovitis Using Ex vivo Human Synovial Tissue with Preserved Function and Architecture

Published on: March 20, 2026

A 3D System for Culturing Human Articular Chondrocytes in Synovial Fluid

A 3D System for Culturing Human Articular Chondrocytes in Synovial Fluid

Published on: January 31, 2012

Related Experiment Videos

Last Updated: Jul 13, 2026

A Friction Testing-Bioreactor Device for Study of Synovial Joint Biomechanics, Mechanobiology, and Physical Regulation

A Friction Testing-Bioreactor Device for Study of Synovial Joint Biomechanics, Mechanobiology, and Physical Regulation

Published on: June 2, 2022

A Pre-Clinical Model of Synovitis Using Ex vivo Human Synovial Tissue with Preserved Function and Architecture

A Pre-Clinical Model of Synovitis Using Ex vivo Human Synovial Tissue with Preserved Function and Architecture

Published on: March 20, 2026

A 3D System for Culturing Human Articular Chondrocytes in Synovial Fluid

A 3D System for Culturing Human Articular Chondrocytes in Synovial Fluid

Published on: January 31, 2012

Area of Science:

Biomaterials Science
Cell Biology
Rheumatology

Background:

Temporomandibular joint (TMJ) synovitis is associated with compressive stress, but the underlying mechanisms remain unclear.
Mechanical stress on TMJ synovial cells may induce degenerative changes in temporomandibular joint disease.

Purpose of the Study:

To investigate the effects of cyclic compressive loading on human TMJ synovium-derived cells in vitro.
To elucidate the role of mechanical stress in TMJ synovitis and degenerative processes.

Main Methods:

Human TMJ synovium-derived cells were cultured on collagen scaffolds to create 3D constructs.
Cyclic compressive loading was applied using a custom apparatus.
Analysis included DNA content, apoptosis, inflammatory cytokine mRNA, and matrix metalloproteinase (MMP) expression and activity.

Main Results:

Cyclic compression did not alter DNA amount or apoptotic cell numbers.
MMP-2, MMP-3, and IL-8 mRNA expression increased significantly with compression.
MMP-1 and MMP-3 protein expression and MMP-2 activity were detected post-compression.

Conclusions:

Compression of human TMJ synovium-derived cells modulates inflammatory cytokine and MMP expression.
These findings suggest a potential mechanism linking mechanical stress to TMJ synovitis and degenerative changes.