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Measurement of Pulse Propagation Velocity, Distensibility and Strain in an Abdominal Aortic Aneurysm Mouse Model
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Assessment of arterial distensibility in patients with cardiac syndrome X

Mustafa Yildiz1, Armagan Altun, Gultac Ozbay

  • 1Department of Cardiology, School of Medicine, Trakya University, Edirne, Turkey. mustafayilldiz@yahoo.com

Angiology
|July 27, 2007
PubMed

Insights

Patients with cardiac syndrome X exhibit decreased arterial distensibility, indicated by increased carotid-femoral pulse wave velocity. This suggests a generalized vascular disturbance, highlighting pulse wave velocity as a key risk indicator.

Area of Science:

  • Cardiovascular Medicine
  • Vascular Physiology

Background:

  • Cardiac Syndrome X (CSX) is characterized by angina-like chest pain without obstructive coronary artery disease.
  • The underlying pathophysiology of CSX remains incompletely understood, with potential links to endothelial dysfunction and microvascular abnormalities.

Purpose of the Study:

  • To investigate arterial distensibility in patients with CSX using carotid-femoral pulse wave velocity (cf-PWV).
  • To determine if cf-PWV can serve as a noninvasive marker for identifying vascular risk in CSX patients.

Main Methods:

  • Carotid-femoral pulse wave velocity (cf-PWV) was measured in 10 patients diagnosed with CSX and 10 age-matched healthy controls using a Complior Colson device.
  • Standard anthropometric and hemodynamic parameters (age, weight, height, BMI, blood pressure, heart rate) were recorded for all participants.

Main Results:

  • Patients with CSX demonstrated significantly increased cf-PWV compared to healthy controls (10.25 ± 1.28 m/s vs. 8.95 ± 0.89 m/s, p = 0.01).
  • No significant differences were observed in age, weight, height, BMI, waist/hip ratio, blood pressure, or heart rate between the groups.
  • No significant correlations were found between cf-PWV and the measured anthropometric or hemodynamic parameters within the study groups.

Conclusions:

  • Arterial distensibility is reduced in patients with Cardiac Syndrome X, as evidenced by elevated cf-PWV.
  • The findings suggest that CSX may involve a more generalized disturbance of the vasculature beyond the coronary arteries.
  • cf-PWV measurement offers a simple, noninvasive method for assessing vascular risk in patients with CSX.

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