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Updated: Jul 13, 2026

Breath Collection from Children for Disease Biomarker Discovery
Published on: February 14, 2019
Poor perception of dyspnoea in children with undiagnosed asthma
R van Gent1, L E M van Essen-Zandvliet, M M Rovers
1Department of Paediatrics, Máxima Medical Center, 5500 MB, Veldhoven, The Netherlands. R.vanGent@mmc.nl
Insights
Children with undiagnosed asthma perceive shortness of breath less intensely than those with diagnosed asthma, even with similar airway hyperresponsiveness. This highlights differences in dyspnoea perception in pediatric asthma.
Area of Science:
- Pediatric Pulmonology
- Respiratory Medicine
- Clinical Research
Background:
- Asthma is a common chronic respiratory disease in children.
- Accurate assessment of asthma symptoms, including dyspnoea, is crucial for effective management.
- Differences in dyspnoea perception between diagnosed and undiagnosed pediatric asthma populations are not well-established.
Purpose of the Study:
- To investigate and compare the perception of dyspnoea in children with undiagnosed versus diagnosed asthma.
- To analyze the relationship between bronchial hyperresponsiveness and dyspnoea perception in these groups.
Main Methods:
- A cross-sectional community-based study involving 1,758 children.
- Parental questionnaires for respiratory health, airway reversibility, and bronchial hyperresponsiveness (BHR) testing.
- Dyspnoea perception assessed using Borg and Visual Analogue Scales (VAS) in children with positive BHR.
Main Results:
- 70 children had undiagnosed asthma and 38 had diagnosed asthma.
- Children with undiagnosed asthma exhibited less steep Borg and VAS slopes compared to diagnosed asthma patients.
- Undiagnosed asthma patients with BHR reported a worse perception of dyspnoea than diagnosed asthma patients.
Conclusions:
- Children with undiagnosed asthma may have a blunted perception of dyspnoea compared to those with diagnosed asthma, despite similar BHR.
- These findings suggest potential differences in how children with undiagnosed asthma experience and report respiratory symptoms.
- Further research is warranted to understand the clinical implications of these perceptual differences in pediatric asthma management.
Abstract:
The aim of the present study was to establish the differences in dyspnoea perception between children with undiagnosed and diagnosed asthma. A cross-sectional community-based study was performed, which included a parental questionnaire on the child's respiratory health and testing of airway reversibility and bronchial hyperresponsiveness (BHR). "Diagnosed asthma" was defined by a physician's diagnosis of asthma. "Undiagnosed asthma" was defined by the presence of asthma symptoms combined with either airway reversibility or BHR without a physician's diagnosis of asthma. Only children with a positive BHR test were selected for further analysis. Perception of dyspnoea was assessed using the Borg scale and the visual analogue scale (VAS), plotted against the percentage fall in forced expiratory volume in one second and expressed as the slope of the regression line. Of the initial 1,758 participating children, 70 had undiagnosed asthma and 38 had diagnosed asthma. The Borg and VAS slopes in children with undiagnosed asthma were less steep than those of children with diagnosed asthma (Borg: 0.07 and 0.14, respectively; VAS: 0.06 and 0.11, respectively). Among children with bronchial hyperresponsiveness, those without a parent's report of physician's diagnosis of asthma had a worse perception of dyspnoea than children with diagnosed asthma.
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