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Updated: Jul 13, 2026
A Piglet Model of Neonatal Hypoxic-Ischemic Encephalopathy
Published on: May 16, 2015
Nitrotyrosine in human neonatal spinal cord after perinatal asphyxia
Floris Groenendaal1, Johannes Vles, Harry Lammers
1Department of Neonatology, University Medical Center Utrecht, Utrecht, The Netherlands. F.Groenendaal@umcutrecht.nl
Background:
Spinal cord injury has been reported after perinatal asphyxia in full-term neonates.
Objectives:
To examine the role of excessive nitric oxide production in perinatal spinal cord injury.
Subjects And Methods:
Tissue samples of 18 full-term neonates who died of hypoxic-ischemic encephalopathy were analyzed for the presence of nitrotyrosine (NT).
Results:
NT was demonstrated in 5 of these 18 neonates. In addition, activated caspase 3, a marker of apoptosis, and CD68, as a marker of inflammation, could be demonstrated in some infants.
Conclusions:
excessive nitric oxide production and subsequent NT formation is seen in spinal cord tissue after severe perinatal asphyxia. This finding may be relevant for the development of neuroprotective strategies.
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