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Updated: Jul 13, 2026

High-Throughput Small Molecule Drug Screening For Age-Related Sleep Disorders Using Drosophila melanogaster
Published on: October 20, 2023
[Misuse of sleep and wakefulness drugs: from undesirable effects to addiction]
1Fédération des Unités d'Explorations et de Traitements des Troubles du Sommeil de Lyon, Inserm E 342, Université Claude Bernard, IFNL, Unité d'Hypnologie, Hôpital Neurologique, 59 boulevard Pinel F 69677 Bron. bastuji@univ-lyonl.fr
Abstract:
Sleep disorders, mainly insomnia and daytime somnolence, can arise from very different causes. For example insomnia may be related to anxiety-depression or occur in response to a stressful lifestyle or as an element of restless leg syndrome. Subjects with hypersomnia may present episodes of sleep apnea, drug-related depression or narcolepsia. Specific management is required for each etiology. Misuse of sleep drugs generally results from an insufficient etiological diagnosis and a misunderstanding of their proper use. These drugs can be used as necessary expedients but cannot replace correct management or treatment of the cause or causes of the sleep disorder. We present here a review of the undesirable effects, particularly among the elderly population, and of the risk of addiction to the different drugs used to induce sleep in order to propose prescription guidelines.
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