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Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes
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Published on: August 20, 2007

What does the future hold for cell-based tolerogenic therapy?

Jeffrey A Bluestone1, Angus W Thomson, Ethan M Shevach

  • 1Immune Tolerance Network and of the Diabetes Center at the University of California, USA.

Nature Reviews. Immunology
|July 27, 2007
PubMed

Evidence from animal models has shown that the transfer of regulatory T cells or tolerogenic dendritic cells can prevent or cure transplant rejection or re-establish self-tolerance in autoimmune disease. The potential of these tolerogenic cells for the treatment of T-cell-mediated diseases in humans has gained momentum in recent years. Here, Nature Reviews Immunology asks four leading researchers to provide their view on the future of cell-based tolerogenic therapy and to highlight some important issues that must be considered before this form of immunotherapy can become a reality.

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