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Updated: Jan 7, 2026

Environmental Modulations of the Number of Midbrain Dopamine Neurons in Adult Mice
Published on: January 20, 2015
A lipid-based model for the creation of an escape hatch from the endoplasmic reticulum
1Whitehead Institute, MIT Department of Biology, Cambridge, Massachusetts 02142, USA. ploegh@wi.mit.edu
Abstract:
Lipids are not encoded by a DNA template and therefore cannot be mutated, knocked out or knocked down. This by no means renders them impotent from a cell biological perspective. Here I propose a model for the involvement of lipid rearrangements in the execution of crucial steps in (glyco)protein quality control.
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