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Related Experiment Video

Updated: Jul 13, 2026

Quantitative Analysis of Dietary Vitamin A Metabolites in Murine Ocular and Non-Ocular Tissues Using High-Performance Liquid Chromatography

Quantitative Analysis of Dietary Vitamin A Metabolites in Murine Ocular and Non-Ocular Tissues Using High-Performance Liquid Chromatography

Published on: December 27, 2024

Vitamin D receptor: a highly versatile nuclear receptor.

¹Department of Pharmacy Practice, University of Illinois at Chicago, Chicago, Illinois 60612-7230, USA. jrwuwong@uic.edu

Kidney International

|July 27, 2007

Summary

Vitamin D receptor (VDR) modulators may reduce cardiovascular disease (CVD) risk in chronic kidney disease (CKD) patients. Research suggests VDR regulates a key receptor in kidney cells, potentially explaining this protective effect.

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Last Updated: Jul 13, 2026

Quantitative Analysis of Dietary Vitamin A Metabolites in Murine Ocular and Non-Ocular Tissues Using High-Performance Liquid Chromatography

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Published on: December 27, 2024

Real-time Analyses of Retinol Transport by the Membrane Receptor of Plasma Retinol Binding Protein

Real-time Analyses of Retinol Transport by the Membrane Receptor of Plasma Retinol Binding Protein

Published on: January 28, 2013

Area of Science:

Nephrology
Endocrinology
Cardiovascular Research

Background:

Hyperparathyroidism is common in chronic kidney disease (CKD).
Vitamin D receptor (VDR) modulators treat secondary hyperparathyroidism in CKD.
CKD patients have high cardiovascular disease (CVD) mortality.

Purpose of the Study:

To investigate the role of VDR in regulating cardiovascular function in CKD.
To explore potential mechanisms linking VDR activation to reduced CVD risk in CKD.

Main Methods:

Study focused on inner medullary collecting duct cells.
Investigated the interaction between VDR and type A natriuretic peptide receptor (NPR-A).

Main Results:

VDR was found to be involved in regulating NPR-A expression and function.
This regulation may be a key pathway for VDR's cardioprotective effects.

Conclusions:

VDR activation may mitigate CVD risk in CKD patients through NPR-A regulation.
Further research into VDR-NPR-A pathways could yield new therapeutic strategies for CKD-related CVD.