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A Non-Coding Small RNA MicC Contributes to Virulence in Outer Membrane Proteins in Salmonella Enteritidis
Published on: January 27, 2021
Microcins, gene-encoded antibacterial peptides from enterobacteria.
Sophie Duquesne1, Delphine Destoumieux-Garzón, Jean Peduzzi
1Laboratory of Chemistry and Biochemistry of Natural Substances, UMR 5154 CNRS, Department of Regulations, Development and Molecular Diversity, National Museum of Natural History, CP 54, 57 rue Cuvier, 75005, Paris, France.
Natural Product Reports
|July 27, 2007
Summary
Microcins are small, gene-encoded antibacterial peptides produced by enterobacteria. This review details their diverse structures, synthesis, and mechanisms, highlighting their potential as novel antibiotics.
Area of Science:
- Microbiology
- Biochemistry
- Molecular Biology
Background:
- Microcins are gene-encoded antibacterial peptides (<10 kDa) produced by enterobacteria.
- They are ribosomally synthesized, unlike many other microbial antibiotics.
- Their genetic clusters include precursors, immunity factors, and secretion proteins.
Purpose of the Study:
- To provide an updated overview of microcins.
- To cover their structures, antibacterial activities, genetic systems, and biosynthesis.
- To discuss their mechanisms of action.
Main Methods:
- Literature review of reported microcins.
- Analysis of genetic clusters and biosynthesis pathways.
- Examination of structural diversity and antibacterial mechanisms.
Main Results:
- Fourteen microcins have been reported, with seven characterized.
- Microcins exhibit diverse structures and antibacterial mechanisms.
- They are synthesized via ribosomal pathways with post-translational modifications.
Conclusions:
- Microcins represent a distinct class of potent antibacterial peptides.
- Despite limited characterization, they show significant structural and mechanistic diversity.
- Further research into microcins could yield novel antibiotic strategies.
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