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Low-temperature sterilization and new technologies.

Vania Regina Goveia1, Silma Maria Cunha Pinheiro, Kazuko Uchikawa Graziano

  • 1College of Nursing, Brazil, University of São Paulo, Brazil.

Revista Latino-Americana De Enfermagem
|July 27, 2007
PubMed
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New low-temperature sterilization methods offer alternatives to ethylene oxide. Their effectiveness depends on equipment choice and device cleanliness, with limitations for bone grafts and material properties.

Area of Science:

  • Medical Technology
  • Infectious Disease Control
  • Material Science

Background:

  • Ethylene oxide sterilization poses risks, driving the need for safer alternatives.
  • Low-temperature sterilization technologies are emerging as viable replacements.
  • Assessing antimicrobial activity, toxicity, and applicability is crucial for adoption.

Purpose of the Study:

  • To review evidence on the antimicrobial activity, toxicity, adverse events, and applicability of new low-temperature sterilization technologies.
  • To identify factors influencing the efficacy of these sterilization methods.
  • To highlight limitations and considerations for implementing low-temperature sterilization.

Main Methods:

  • Systematic literature review of studies published up to 2005.

Related Experiment Videos

  • Searches conducted in MEDLINE and LILACS electronic databases.
  • Analysis of 10 selected articles focusing on sterilization efficacy and parameters.

    • Main Results:

    • Efficacy is influenced by lumen dimensions (length, diameter) and the presence of crystal salts.
    • Proper equipment selection and thorough device cleaning are critical for effective sterilization.
    • Limitations exist for sterilizing bone grafts and potential adverse effects on material properties were noted.

    Conclusions:

    • Low-temperature sterilization technologies show promise but require careful application.
    • Device preparation and equipment parameters significantly impact sterilization outcomes.
    • Further research is needed to fully understand material compatibility and long-term effects.