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Updated: Jun 29, 2026
A Procedure for Studying the Footshock-Induced Reinstatement of Cocaine Seeking in Laboratory Rats
Published on: January 7, 2011
Subsequently enhanced CPP to morphine following chronic but not acute footshock stress associated with corticosterone
Yan Li1, Gong-Ying Li, Ling-Jiang Li
1Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha Hunan, PR China.
Abstract:
The purpose of this study was to determine the morphine-induced place preference in rats pre-exposed to footshock stress and corticosterone (CORT). The authors also studied the involvement of dopamine mechanisms in the CORT-induced place preference. The results showed that chronic footshock or CORT exposure but not acute footshock or CORT exposure similarly potentiated the conditioned place preference to morphine. The CORT-induced conditioned place preference were established only with high and middle dose (5, 3 mg/kg) CORT. The dopamine levels in NAc of rats injected with CORT (5, 3, 1 mg/kg, i.p.) increased significantly. The findings suggest that the increase of dopamine levels in NAc induced by CORT might be the medium between stress and morphine.
